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    New Chief Executive of NICE

    NHS insider, to be seen how she adapts to independent role: https://www.ahsnnetwork.com/interview-dr-sam-roberts-chief-executive-accelerated-access-collaborative And recently in the privater sector: https://blog.congenica.com/congenica-appoints-dr-sam-roberts-as-non-executive-director
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    Science Advances: The Human Proteoform Project: Defining the human proteome, 2021, Lloyd M. Smith et al

    The Human Proteoform Project: Defining the human proteome Lloyd M. Smith, Jeffrey N. Agar, Julia Chamot-Rooke, Paul O. Danis, Ying Ge, Joseph A. Loo, Ljiljana Paša-Tolić, Yury O. Tsybin, Neil L. Kelleher Abstract Proteins are the primary effectors of function in biology, and thus, complete...
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    Can Understanding Gut-Brain Axis Biopsychosocial Pathways Improve Clinical Reasoning?, 2021, Ford et al

    To use a social media vernacular: "What fresh hell is this ?" Not just a single "Theory" in which to cram the patient but seven !
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    Unexpectedly high prevalence of primary immune deficiency in fibromyalgia: serologic features and clinical correlates, 2021, Caro and Winter

    Affiliation with a Psychology Dept doesn't necessarily mean that the affiliate is a Psychologist, or doesn't have additional academic or practical skills. Other than publishing with Caro, Winter doesn't seem to have an academic presence - may now be retired, and is simply referencing a...
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    Insulin Resistance Is Associated with Multiple Chemical Sensitivity in a Danish Population-Based Study—DanFunD, 2021, Bjerregaard et al

    Insulin resistance and impaired glucose metabolism might not be unrelated to the substantially higher number of obese subjects in the MCS and MCS+FSD groups compared to controls !
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    Interplay between genetics and lifestyle on pain susceptibility in women with fibromyalgia: The al-Ándalus project, 2021, Estévez-López et al

    Assuming that the methodology is sound (no controls and a smallish sample might be a concern, but perhaps not relevant for this kind of study) then this looks not unreasonable. The Conclusion: offers a falsifiable hypothesis - "activity increase in fibromyalgia sufferers with genetic...
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    Interpreting physical sensations to guide health-related behavior, 2021, Fazekas et al

    Truly dreadful. Asserts actual biological effects from arcane practices but quoted sources either involve non significant studies or simply behaviour change. One of the quoted authors has had the Jim Coyne treatment...
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    What differentiates ME/CFS from known primary mitochondrial diseases; could mitochondrial disease cause PEM?

    Fantasy Evolutionary Biology is a limitless game - there's always something to add in or take away to get a result that fits and it can be quite fun, but we are not talking falsifiable hypotheses. In this case the starting point seems to be the fairly well researched field of sickness behaviour...
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    Testing a newly developed activity pacing framework for chronic pain/fatigue: a feasibility study, Antcliffe et al 2021

    Words, as Humpty Dumpty said are all about who is master: WHO = Rehabilitation is defined as “a set of interventions designed to optimize functioning and reduce disability in individuals with health conditions in interaction with their environment”.
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    Using Communities of Practice Theory to Understand the Crisis of Identity in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME), 2021, Murray

    I don't think it strange question at all. There's a major disconnect in much of Sociology where supposed real interactions with actual people are stripped of character in the service of validation of 'theory'. In this paper we are given a glimpse of a few real voices, though edited to fit the...
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    Using Communities of Practice Theory to Understand the Crisis of Identity in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME), 2021, Murray

    IMO Sociology lost its way after the passing of Max Weber - a mere 101 years ago, this article doesn't persuade me my opinion is wrong. Perhaps I missed it but I couldn't detect a single test of assumption anywhere, it's polemic not investigation. I need to go listen to some death metal to clear...
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    Rapid volumetric brain changes after acute psychosocial stress, 2021, Marie Uhlig et al

    What seems surprising is the rapidity and scale of the physiological response - so perhaps a scanning artifact or just increased blood flow. And maybe it's a study that is only negatively pertinent here because of the 'never demonstrated to be relevant' putative role of stress in ME/CFS. I...
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    Rapid volumetric brain changes after acute psychosocial stress, 2021, Marie Uhlig et al

    Rapid volumetric brain changes after acute psychosocial stress Marie Uhlig, Janis D. Reinelt, Mark E. Lauckner, Deniz Kumral, H. Lina Schaare, Toralf Mildner, Anahit Babayan, Veronika Engert, Arno Villringer, Michael Gaebler Abstract "Rapid structural brain plasticity after acute stress has...
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    Sexual Desire, Depressive Symptoms and Medication Use Among Women With Fibromyalgia in Flanders, 2021, Van Overmeire et al

    There's certainly some evidence to support SSRI use in pain management, though there appears to be different pain reducing effects depending which particular drug is used https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947493/ There is said to be (by online unreferenced sources !) a lot of...
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    The experiences of adolescents diagnosed with functional gastrointestinal disorders: An interpretative phenomenological analysis, 2021, Woodham et al

    In this context "it is considered" is I think meant as speech from authority, rather than hearsay. They are saying 'we (in our wisdom) consider this to be true' . Hearsay in a legal sense is complicated, how it is treated very much depends on jurisdiction, for example...
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    Open University of Oxford: CFS study: Researching the biochemistry of Chronic Fatigue Syndrome, closes 30th Dec 2022

    Off topic but an interesting coincidence: An established company in the business that Lindushealth is seeking to break into is Simbec Orion - set up over 40 years ago as Simbec Research by one Mansel Aylward. Very much on the boo hiss scale for us because of his championing BPS approaches and...
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    Covid-19 vaccines and vaccinations

    I think JE's subsequent reply covers most of what can currently be said. The one thing I'd add is that the age gradient, where we see vulnerability to this particular virus increasing with age, probably isn't smooth, so that a 40 year old isn't mid way between a 5 year old and a 75 year old...
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    Sexual Desire, Depressive Symptoms and Medication Use Among Women With Fibromyalgia in Flanders, 2021, Van Overmeire et al

    Too early for research prompted by the NICE outcome to be being published. I think researchers across a number of fields would probably say that the impact of illness and disability on sexual function has been a neglected area and that needs to change, it's inevitable that there would be a...
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    Covid-19 vaccines and vaccinations

    Simple answer is Yes. There have been trials for all the booster vaccines being used in the UK - link here is for the BNT162b2 https://www.nejm.org/doi/full/10.1056/NEJMc2113468
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