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Abstract Acetylcholine (ACh) is best known as a neurotransmitter and was the first such molecule identified. ACh signalling in the neuronal cholinergic system has long been known to regulate numerous biological processes (reviewed by Beckmann and Lips). In actuality, ACh is a ubiquitous...

Peer review information Nature Reviews Cardiology thanks Svetlana Blitshteyn, David Goldstein and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.

Abstract Purpose Cognitive behavioural therapies (CBTs) are a standard of care for treatment of many ‘hidden symptoms’ in people with MS (PwMS), such as stress, depression, and fatigue. However, these interventions can vary widely in formatting and may not be tailored for PwMS. To optimize CBTs...

Published papers thread for w/c 8th Jan. Facebook: https://www.facebook.com/sci4me/posts/pfbid02wKEdtNhqLCtdQ89WdwdZQegnXr3xoUo7KuxcZY7LPmEyPqUPobxkVuwVtmCM5sP7l Mastodon: https://med-mastodon.com/@s4me/111759505741210749

A few comments, all with the proviso that I understand creating a good questionnaire is challenging. Given that the questionnaire says, "Items described include necessary activities to perform them. Example: "Going to a shop for groceries" includes getting dressed and as necessary travelling."...

Abstract Objective Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a disorder characterized by debilitating fatigue accompanied by pain and impairments in memory, cognition, and concentration. Acetylcholine (ACh) has a plethora of roles in neuronal and neuromuscular transmission...

For what it is worth. Some people report benefit from Mestinon. Mestinon is pyridostigmine bromide. From Wikipedia, "Pyridostigmine bromide has been FDA approved for military use during combat situations as an agent to be given prior to exposure to the nerve agent Soman in order to increase...

Abstract The aetiology of chronic fatigue syndrome (CFS) remains controversial and a number of hypotheses have been put forward to explain it. Research into the condition is hindered by the considerable heterogeneity seen across patients but several reports have highlighted disturbances to...

Summary Although the aetiology of chronic fatigue syndrome (CFS) is unknown, there have been a number of reports of blood flow abnormalities within the cerebral circulation and systemic blood pressure defects manifesting as orthostatic intolerance. Neither of these phenomena has been explained...

Given that 2 years ago Mango reported, about a different paper, that he really shouldn't be now claiming ignorance around the issue of GET and PACE.

News in Brief posts for w/c 8th Jan. Facebook: https://www.facebook.com/sci4me/posts/pfbid02tdW38uB1o67Rwand4LLAimUcTpZ1LipDjReuBdxPCmfz4KvdbQ53wMme3TX4jVSKl Mastodon: https://med-mastodon.com/@s4me/111754020268199671

9,863 signatures at time of posting. https://www.change.org/p/cochrane-withdraw-the-harmful-2019-exercise-therapy-for-cfs-review

Unless his future actions and words prove otherwise, I assume that this is just more positioning to attempt to maintain FND concepts as relevant, rather than accepting that it is a waiting room for issues that currently science either can't explain or hasn't properly investigated. Even him...

[Don't get your hopes up, this is not Stone's announcement of his retirement] The diagnosis of functional neurological disorder (FND) has rested traditionally on two key features: inconsistency and incongruency. Inconsistency usually refers to inconsistency between movement, sensory or...

Posting this here as no abstract or working link to journal is available at time of posting. Functional neurological disorder: defying dualism, 2024, Jon Stone, Ingrid Hoeritzauer, Laura McWhirter and Alan Carson Pubmed, https://pubmed.ncbi.nlm.nih.gov/38214630/

Trial By Error: Study Finds “Elevated Brain Injury Markers and Reduced Grey Matter Volume” a Year After Hospitalization for COVID-19 A British study of neurological sequelae in patients many months after hospitalization for COVID-19 has found that “post acute cognitive deficits…were associated...

Apparently not, but very similar. See A safe and effective micro‑choice based rehabilitation for patients with long COVID: results from a quasi‑experimental study 2023, Frisk et al

Neither the ICC, CCC or IOM criteria for ME/CFS require PEM to be delayed. While I am fully in agreement that PEM should be defined as something that occurs after an unusually long delay, currently it isn't, so it seems to me that the authors are justified in calling what they are studying PEM.

From the paper, "The most reported symptoms of long COVID include limited exercise tolerance and post-exertional malaise, representing the worsening of symptoms after mental or physical exertion" and "In this study, we systematically induced post-exertional malaise in a cohort of 25...

Does the paper claim to account for PEM caused by mental exertion?