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‘It’s insane’: New viruslike entities found in human gut microbes As they collect and analyze massive amounts of genetic sequences from plants, animals, and microbes, biologists keep encountering surprises, including some that may challenge the very definition of life. The latest, reported this...

Link to post with published version Preprint Abstract Here, we describe the “Obelisks,” a previously unrecognised class of viroid-like elements that we first identified in human gut metatranscriptomic data. “Obelisks” share several properties: (i) apparently circular RNA ∼1kb genome...

Lupus Tracked to Changes in a Single Gene That Tames The Immune System Led by the Max Planck Institute for Infection Biology in Germany, the team discovered that a group of proteins called the BORC complex is needed to properly break down a protein called toll-like receptor 7 (TLR7). TLR7...

Abstract Hyperactive TLR7 signaling has long been appreciated as driver of autoimmune disease in mouse models. Recently, gain-of-function mutations in TLR7 were identified as a monogenic cause of human lupus. TLR7 is an intracellular transmembrane receptor, sensing RNA breakdown products within...

This page, https://www.nhs.uk/conditions/chronic-fatigue-syndrome-cfs/, says Page last reviewed: 29 October 2021 Next review due: 29 October 2024 Perhaps what was meant on Twitter was that following the new NICE guideline the page was rewritten, as that would then seem to fit with the...

News in Brief posts for w/c 22nd Jan. Facebook: https://www.facebook.com/sci4me/posts/pfbid0a2WnKzog3jgUtwLoHJFiv6aemHUFtmbp7e7szoaVBgyqh3FPhzi2YukgG5jQAFehl Mastodon: https://med-mastodon.com/@s4me/111833019631539136

Trial By Error: Debate Over Recent Citation of Arguably Fraudulent PACE Trial Professor Fedorovski et al conclude their response with this: “The jury is still out; we should wait for the verdict and respect it when it comes.” No, the jury is not “still out” when it comes to the PACE trial...

Some interesting use of language in this section as well. "PEM is a crucial source of suffering in the majority of ME/CFS patients" isn't how I would have chosen to describe it. My guess is that they are trying to say that PEM is a core symptom? "Fatigue pathology: MS, ME/CFS, Long COVID 1.4...

They also say this "Functional Somatic Disorders (FSD) refer to clusters of recurrent disabling bodily symptoms (e.g. chronic fatigue, pain) and are prevalent in all medical settings [1]. FSD cannot be better explained by other somatic or psychiatric condition and varies from mild to severe...

Abstract Objectives Earlier studies on the association between plasma lipid profiles and functional somatic disorders (FSD) are mainly small case control studies hampered by selection bias and do not consider the great overlap between the various FSDs. The aim of the present study was to...

"3.1. Myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS) ME/CFS is a serious, long-term, multi-system disorder characterised by a wide range of symptoms including extreme fatigue, autonomic and cognitive dysfunction, sleep disturbances and pain. ME/CFS affects motor, sensory and...

Highlights Though a common symptom, fatigue is difficult to define and investigate, and occurs in a wide variety of disorders, with differing pathological causes. This review aims to guide clinicians in how to approach fatigue and to suggest that neurophysiological tests may allow an...

10, 064 signatures at time of posting. https://www.change.org/p/cochrane-withdraw-the-harmful-2019-exercise-therapy-for-cfs-review

Opinion: The BBC and Dragons’ Den have let down ME patients https://inews.co.uk/opinion/bbc-dragons-den-let-down-me-patients-2875435

Prevalence of associated conditions and surgeries (click to expand) No mention of ME/CFS, or fatigue.

"Functional somatic disorder (FSD) is a unifying diagnosis that includes a range of functional somatic syndromes (FSS) such as irritable bowel syndrome, fibromyalgia and chronic fatigue syndrome, and it can be conceptualised as the diagnostic concept bodily distress syndrome.Reference Burton...

Full title: Neuroticism, perceived stress, adverse life events and self-efficacy as predictors of the development of functional somatic disorders: longitudinal population-based study (DanFunD) Abstract Background Functional somatic disorder (FSD) is a unifying diagnosis that includes...

ABSTRACT Purpose Treatments for myalgic encephalomyelitis and chronic fatigue syndrome can be adapted for post–COVID-19 condition. Our aim was to compare treatments in patients from our post–COVID-19 clinic. Methods We conducted a retrospective cohort study and included consecutive patients...

Thanks Wyva, I'll pass details on to the team. Here are further details about the project. Abstract While it is known that post-COVID-19-condition (PCC) is caused by SARS-CoV-2 infection, for most other immune-related noncommunicable diseases (IR-NCDs), no such infectious disease (ID) triggers...

@DMissa , is it this research that you will be talking about at UK: Conference: MitOX 2024, 12th April 2024