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  1. Andy

    Reflections on the CODES trial for adults with dissociative seizures: what we found and considerations for future studies 2024 Stone, Carson, Chalder+

    Abstract The COgnitive behavioural therapy versus standardised medical care for adults with Dissociative non-Epileptic Seizures multicentre randomised controlled trial is the largest, fully-powered study to test the clinical and cost-effectiveness of a psychotherapeutic intervention in this...
  2. Andy

    Closed UK: DecodeME updates, was recruitment thread.

    Job description Summary: Job Title: Communications and Engagement Officer Reports to: Research Manager Salary: Up to £30,000 FTE Annual Leave: 30 days + 8 bank holidays / annum FTE Contract Type: Fixed Term Contract to 31st August 2025 Hours of work: Full time (35 hrs per week). We...
  3. Andy

    Stigmatisation in clinical consultations for persistent physical symptoms/functional disorders: A best fit framework synthesis, 2024, Treufeldt et al

    Thread on ETUDE here, https://www.s4me.info/threads/etude-encompassing-training-in-functional-disorders-across-europe.16016/
  4. Andy

    Review Peripheral to brain and hippocampus crosstalk induced by exercise mediates cognitive and structural hippocampal adaptations 2024 Blume and Royes

    Abstract Endurance exercise leads to robust increases in memory and learning. Several exercise adaptations occur to mediate these improvements, including in both the hippocampus and in peripheral organs. Organ crosstalk has been becoming increasingly more present in exercise biology, and...
  5. Andy

    Loss and Return of Ticklishness in Functional Neurological Disorder 2024 Coebergh, Edwards et al

    Abstract Background People with functional neurological disorder (FND) have abnormalities in sensory processing. Loss of ticklishness has been rarely reported. Objectives To describe associated clinical features in people with FND and loss of ticklishness and explore correlations with sensory...
  6. Andy

    Esther Crawley

    Dave Tuller reports on Twitter that "Professor Esther Crawley apparently relinquished her right to practice medicine last September, according to the UK's General Medical Council, which oversees physicians. No explanation provided. 1/ gmc-uk.org/doctors/3545946"
  7. Andy

    International: Science for ME social media posts

    Published papers thread for w/c 3rd June. Facebook: https://www.facebook.com/sci4me/posts/pfbid02qXAmA3JdCz9ERuBfwRcPtWunkKR4HRZQ4T1Q7epYJNpxe4yk1hT9nfnUaFELQAKWl Mastodon: https://med-mastodon.com/@s4me/112591835650713843
  8. Andy

    #MEAction UK: Questions to Ask Prospective MPs About ME/CFS

    Unfortunately I feel that providing a figure that misrepresents the likely scale is as unhelpful. Issues with the CDC survey from the States that is used to calculate that number can be found here, CDC Data Brief: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in Adults: United States...
  9. Andy

    Stigmatisation in clinical consultations for persistent physical symptoms/functional disorders: A best fit framework synthesis, 2024, Treufeldt et al

    See also Stigmatisation in medical encounters for persistent physical symptoms/functional disorders: scoping review and thematic synthesis, 2024, Treufeldt Persistent somatic symptom related stigmatisation by healthcare professionals: A systematic review... 2023 McGhie-Fraser et al
  10. Andy

    Stigmatisation in clinical consultations for persistent physical symptoms/functional disorders: A best fit framework synthesis, 2024, Treufeldt et al

    Highlights In consultations for PPS/FDs, stigmatisation can occur in various ways in the communication process. Current models do not accurately reflect the patients’ experiences of stigmatisation in their consultations for PPS/FDs. New way to understand and categorise common forms of...
  11. Andy

    #MEAction UK: Questions to Ask Prospective MPs About ME/CFS

    The question I would ask MEAction is why they feel making this claim, "In the UK, there are an estimated 700,000 to 1.2 million people with ME", is useful.
  12. Andy

    International: Science for ME social media posts

    News in Brief posts for w/c 3rd June. Facebook: https://www.facebook.com/sci4me/posts/pfbid0511JA9cQRxmnPSpe9kCkM8XDFaQv661iLFHcTKngvu4GmMJhFKA5Atg5ypu7DFv4l Mastodon: https://med-mastodon.com/@s4me/112586115458574898
  13. Andy

    Open GEM study - Prevalence of genetic diseases in ME/CFS patients, 2022, Esther Crawley, Bristol University

    I've seen on Twitter that apparently the ME Association have highlighted this study in their weekly email newsletter. This is the listing on the Be Part of Research website, https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=11083&location=&distance=, where the contact is...
  14. Andy

    Epithelial hypoxia maintains colonization resistance against Candida albicans 2024 Savage et al

    Highlights C. albicans depletes sorbitol in gnotobiotic mice and needs oxygen to catabolize it E. coli requires oxygen respiration to limit a post-antibiotic C. albicans bloom Depletion of Clostridia by antibiotics disrupts anaerobiosis to boost Candida growth 5-ASA restores epithelial...
  15. Andy

    Prevalence of somatic symptoms among Ebola Virus Disease (EVD) survivors in Africa: a systematic review and meta-analysis 2024 Mandizadza et al

    Background Many Ebola virus disease (EVD) survivors have reported somatic and neuropsychological symptoms after discharge from the Ebola Treatment Unit (ETU). Since the 2014–2016 Ebola epidemic in West Africa, various studies have investigated and identified these symptoms. Evidence on somatic...
  16. Andy

    Chronic fatigue syndrome post-COVID-19: triple-blind randomised clinical trial of Astragalus root extract 2024 Banihashemi et al

    Being paywalled, I am unable to determine how "chronic fatigue syndrome" was specified. Given that they then refer only to chronic fatigue in the later part of the abstract I doubt they used any criteria that screened for PEM.
  17. Andy

    Chronic fatigue syndrome post-COVID-19: triple-blind randomised clinical trial of Astragalus root extract 2024 Banihashemi et al

    Abstract Objective This study aimed to evaluate the effect of Astragalus root extract on nurses suffering from post-COVID-19 chronic fatigue syndrome. Materials and methods The study was designed as a triple-blind, randomised, controlled trial in Iran in 2023. 64 chronic fatigue syndrome...
  18. Andy

    A disease-associated gene desert directs macrophage inflammation through ETS2 [in IBD] 2024 Stankey et al

    My suspicion was correct, the Genetics Delivery Team confirm that DecodeME will "perform a genome-wide association study (GWAS) which covers both coding and non-coding regions of the genome (the later representing more 98% of the genome) rather than looking at specific regions. Actually, the...
  19. Andy

    Petition: S4ME 2023 - Cochrane: Withdraw the harmful 2019 Exercise therapy for CFS review

    Now at 11,111 signatures. https://www.change.org/p/cochrane-withdraw-the-harmful-2019-exercise-therapy-for-cfs-review
  20. Andy

    The MEpedia Primer for Journalists

    My opinion is that if the acronym ME/CFS is going to be used, which I personally favour, then it should be written as, "ME/CFS Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), sometimes referred to as myalgic encephalomyelitis (ME) or chronic fatigue syndrome (CFS) is a serious and...
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