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@dave30th , an 'interesting' one for you.

Introduction The classification of the so-called “functional” psychiatric disorders has long been debated. Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV; 1994) retained the “somatoform” psychological-primacy concept but had poorly devised subdivisions with...

Published papers thread for w/c 1st April. Facebook: https://www.facebook.com/sci4me/posts/pfbid0acxNpGXucCKKiGXnvnJQW3pacwHbBXxV9uPZ14sMunrNpHQMYgfsA4bqz8hLkVdTl Mastodon: https://med-mastodon.com/@s4me/112234932500952686

Abstract Nattokinase, from the Japanese fermented food natto, is a protease with fibrinolytic activity that can thus degrade conventional blood clots. In some cases, however, including in Long COVID, fibrinogen can polymerise into an anomalous amyloid form to create clots that are resistant to...

Trial By Error: My Letter to Scientific Reports about New Study of Physical Activity and Long Covid "The other day I posted a blog about yet another problematic Long Covid study published by a major journal. The study concluded that physical activity (PA) can “reduce” symptoms in young women...

'‘Health and Well-being’ self-care support sessions aim to support self-management of common symptoms and risk factors and to enhance self-management skills, including problem-solving, planning, self-monitoring and cognitive adaptation. The list of core sessions that will be delivered to...

Abstract Introduction Personalised Exercise-Rehabilitation FOR people with Multiple long-term conditions (PERFORM) is a research programme that seeks to develop and evaluate a comprehensive exercise-based rehabilitation intervention designed for people with multimorbidity, the presence of...

News in Brief posts for w/c 1st April. Facebook: https://www.facebook.com/sci4me/posts/pfbid023oqeG7sYeyP5auijB3gZo9b3HmA49zZ6X2TE5mQhAJGnxG8LyTXCGvV7t4ia23ZEl Mastodon: https://med-mastodon.com/@s4me/112229108518479720

Abstract Ehlers–Danlos syndromes (EDS) are a group of connective tissue disorders caused by mutations in collagen and collagen-interacting genes. We delineate a novel form of EDS with vascular features through clinical and histopathological phenotyping and genetic studies of a three-generation...

"The Bill & Melinda Gates Foundation, one of the world’s top biomedical research funders, will from next year require grant holders to make their research publicly available as preprints, articles that haven’t yet been accepted by a journal or gone through peer review. The foundation also said...

Yet it probably won't. The FND researchers will just point at this sort of research, proclaiming 'See, FND is actually a thing, these results prove it!', despite years of advocating for the smallest amount of investigation that can be got away with.

Abstract Objective The role of inflammation and neuroimmune mechanisms, which have been documented in various neuropsychiatric disorders including the seizure subtype of functional neurological disorder, remains unclear in functional movement disorders (FMD). To explore these mechanisms, we...

Abstract Ewing sarcoma is the second most frequent primary bone tumour of childhood and adolescence. The aim of this report is to describe the imaging, pathology, clinical findings, and treatment of a primary intradural extramedullary Ewing sarcoma with a unique intracranial metastatic...

We believe that, unless the planned programming changes, Channel 4 news will have another section on ME/CFS tonight which will, in part, include reporting on DecodeME.

Trial By Error: Yet Another Long Covid Study with Bogus Claims Published by a Prestige Journal "I’ve recently spent some time lambasting a Long Covid study in The BMJ that claimed a rehab program addressing both physical and mental health was “clinically effective”—even though the primary...

Abstract Mast cells (MCs) are known to have a pathological impact in a variety of settings, in particular in allergic conditions. There is also limited evidence implicating MCs in diabetes, raising the possibility that MC function may be influenced by alterations in glucose levels. However, it...

The existence of this scheme was highlighted on Twitter again yesterday.

Abstract Background Chronic Fatigue Syndrome patients suffer from symptoms that cannot be explained by a single underlying biological cause. It is sometimes claimed that these symptoms are a manifestation of a disrupted autonomic nervous system. Prior works studying this claim from the complex...

Abstract Mental fatigue is common in society, but its effects on force production capacities remain unclear. This study aimed to investigate the impact of mental fatigue on maximal force production, rate of force development-scaling factor (RFD-SF), and force steadiness during handgrip...

Highlights Lactate monitoring has the potential to extend beyond applied sports settings and could be used to monitor the physiologic and pathophysiological responses to external and internal stimuli in chronic disease areas such as Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)...