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The first time I took a dose in about 1993 it threw me into a bout of amnesia for a day. We can indeed have adverse effects. ME is so complicated its impossible to make completely reliable assumptions about any treatment.

This comment is mostly not about ME but about older people and fatigue. One of the issues that contributes, probably to a varying degree, is the loss of capacity to convert CoQ9 to CoQ10 which typically begins around 50. CoQ10 supplements might help for older people. There is some limited...

This is my experience. My ferritin was sky high for a while, even higher than most with iron overload, but my iron wasn't. I was nearly anaemic. One point lower and I would have been in the anaemia range. The flip side happens too. My ferritin was high and I carry one gene that predisposes to...

This position is partly why its taken so long. Its not about argument in my view, but mainly medical economics and politics. Which of course require argument to improve, but the failures to recognize the social and political and economic positions delay change.

I was talking about the likelihood of misfolded proteins in ME with Rich van Konyenburg and Martin L Pall in the early 2000s. It seemed so very likely given the absolute requirement for reduced glutathione in folding.

I think that would depend on the size and frequency of upregulation in the cohort.

I suspect the main cause of delay is and has been Covid. The ME/CFS study was halted so they could work on Covid, and I bet they are still mainly working on Covid. They have to complete work on other studies in any spare time they have or can make, and its not a lot.

That is economic and medical politics. I have been warning about this for over a decade, and sent a global advisory way back when to warn the wiki entry was hijacked by special interests. ANY new name will be subject to the same interference, the special interests are embedded with Wikipedia. To...

One further caveat, in individual countries there might be government agencies that set the rules leading to nomenclature changes within a country, and a smaller chance of the ICD (and even DSM) setting an influential claim to a new name. These will not be enough for universal name change though.

This is an absolute requirement in my view. Without reliable biomarkers, and at least a few key insights as to cause related to the biomarkers, its going to be so very hard to convince enough scientists, medical professionals and company and government bureaucrats. Some meeting may be held, we...

Forgot one. An SF36PF of 60 is about equivalent to an 80 year old.

There is a new one, a metanalysis, hence using multiple studies, due out soon. Its not written by the BPS crowd. If I recall correctly David Tuller is one of the authors.

I feel the need to again comment on what I consider PACE's greatest failure. Standard deviation of SF36PF data is improper manipulation of data. PDW wrote a paper showing he knew this in 2007. So its a knowing manipulation of data to derive their intended result, which included their "normal"...

Its the non-biomedical psychiatry that has an issue with it. There is data showing that some drugs have good effect on many patients, including with depression, though I think many are less effective than they claim. This is because of deliberately poor experimental design. I have forgotten all...

This is my long term description of quack marketing, but I can update it. Casually enrol 1000 people without careful characterization. Heck, they can just be customers who pay for a product. Of those 100 might improve or get better but it might not be from the product at all. Of those you can...

To be fair I think they are using somatic as an alternative to biomedical because they do not want to say biomedical. It could easily read "biomedical and mental". As you noted, psychiatrists just call biomedical "somatic" so they can keep the discussion on their ground. My problem is - what...

I know of an Australian male who had an ME or CFS diagnosis (I do not recall which) who was given an FND diagnosis as well.

Some years back I saw a psychiatrist write the same thing about MS in a paper. Its MS and a psych disorder. Together.

In the early 90s one of my early idols in science, Gerald Edelman, whose equations I was using at the time, wrote that the human brain is the most complex thing we are researching in science. Its complexity is extreme due to all the neural connections, associated tissues, and all the...

I have suspected for maybe two decades and a half that our disturbed sleep might be associated with altered circadian patterns of many metabolites. This was my concern in the late 90s when early morning urinary metabolites were first being looked at. Change the time, or have patients with...