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    PEM: a continued stress response / failure to enter a rest-recovery phase?

    Many of us describe it that way, hence my jest.
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    PEM: a continued stress response / failure to enter a rest-recovery phase?

    Finally, proof zombies are real. They are all people death pemed. :)
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    PEM: a continued stress response / failure to enter a rest-recovery phase?

    I think some post exercise hormone responses were investigated by Light and Light (Alan and Kathleen I think) some years back. Some of them are very high even on a logarithmic scale. I do not think this has been properly followed up on but I could be wrong.
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    How long before the misery of ME is taken seriously? and Money’s the motive for calling ME a myth - Sophie Palmer

    Or specific types of activation and associated processes, including metabolic changes. We still do not know how diverse the changes are.
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    Bruce Wampold: How psychotherapy works / The dodo bird verdict

    I have been saying for a long time that psychiatry needs to grow up and do this. Otherwise much of it has no scientific credibility.
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    Economic Cost of Functional Neurologic Disorders: A Systematic Review, 2023, O'Mahony, Edwards et al

    I think this was done decades ago. I wrote a blog on it, I think on Phoenix Rising. I no longer remember the data, but huge numbers were re-diagnosed in time, but only small numbers in a single year. The proponents of this BPS stuff of course dismiss such findings. Of course this was not FND at...
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    Economic Cost of Functional Neurologic Disorders: A Systematic Review, 2023, O'Mahony, Edwards et al

    Plus nearly all transplant surgeries and aftercare. There is still no sound medical basis to this version of FND. They might as well be saying that all difficult medical cases, especially where adequate research has not been done, cost people too much and do not make enough money for big...
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    How long before the misery of ME is taken seriously? and Money’s the motive for calling ME a myth - Sophie Palmer

    Sadly I see this happening to some extent with evidence based medicine now. The movement is failing, but has not fully failed yet. Its just on its way. EBM is the label for the new dogma in the thoughts of most doctors I see. I wonder if more than a small percent could actually tell me the...
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    How long before the misery of ME is taken seriously? and Money’s the motive for calling ME a myth - Sophie Palmer

    I used to call this the two hit hypothesis, but later amended that to the multiple hit hypothesis. I had in mind the staged onset idea as well. Many are sudden onset, a good number slow onset, but some are also staged onset. Each infection makes things worse like going down steps into hell. So I...
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    How long before the misery of ME is taken seriously? and Money’s the motive for calling ME a myth - Sophie Palmer

    If ME is a response to a viral infection its entirely possible that infections that do not show symptoms are a cause. Its also possible that one or more biochemical pathways involved in viral defence might be activated by other triggers. Its the pathways that might be in common more than the...
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    How long before the misery of ME is taken seriously? and Money’s the motive for calling ME a myth - Sophie Palmer

    I regard this as an open question. Its fairer to say that we cannot be sure ME is one disease. It still might be several or many diseases though. We do not have a definitive answer. On the myriad of symptoms, ME is associated with thousands of different biochemical changes, and different...
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    Detection of Elevated Level of Tetrahydrobiopterin in Serum Samples of ME/CFS Patients with Orthostatic Intolerance: A Pilot Study 2023,Gottschalk ea

    If BH4 expression is high it seems it might be protective of something. They hint at this with oxidative stress, but it might not be that, or not only that. If expression is high but we can confirm deficiency then it might be that its not being expressed enough or that its being over-utilized...
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    Reddit - Interesting posts on Reddit, including what some doctors say about ME/CFS

    In any online forum what percentage claiming to be doctors, as in MDs, are actually MDs? How many are trolls? I know from personal experience that prejudice is common, but I also know that hate groups coalesce on the internet and they might not be who they claim to be. Doctors who are trolls or...
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    Associations between daily routines and social support among women with chronic fatigue syndrome 2023 Rosenburg et al

    I wish. I would crash for a month if I drank alcohol. Actually its a biphasic crash, two different crashes, one for a few days, and one for weeks. The action of participating in social activity would crash me too. Its not about can I do it, its about consequences. I have had the experience in...
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    Associations between daily routines and social support among women with chronic fatigue syndrome 2023 Rosenburg et al

    [Satire] CFS patients drink less alcohol, and drinking alcohol is associated with increased social activity, therefore to improve their social activity they need to drink more alcohol. Buy them all beer/wine/spirits! They need it. Sick people participate less. What we need is more research on...
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    Poll: Who will find the answer to ME: Humans or AI?

    It shows that a linguist AI does not understand anything, it just pushes symbols around in hopefully smart-like ways. PS My first degree was in AI but is now more than two decades out of date. PPS AI language using software has to use rules or algorithms, typically heuristic (approximate or...
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    Poll: Who will find the answer to ME: Humans or AI?

    Right now no AI that I have read about understands anything. The current generation seem to just process patterns, and can process huge amounts of data over a very short time in order to find patterns. There is no way humans can be kept out of this loop. What worries me is the propensity for...
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    Poll: Who will find the answer to ME: Humans or AI?

    Current AI will give us answers, but those answers might be nonsense and not pan out. Humans will still be in the mix if an AI comes up with an hypothesis, at least for many years to come. So the answer is either humans or a mix of both, but both possibilities ignore the most important point...
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