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This might be the case but my concern is that its looking like its mass dysregulation, and everyone might be slightly different, leaving no consistent biomarkers. We could do it with a large and well funded prospective study, grabbing blood samples from tens of thousands, doing a new one every...

With my current thinking ME is a dynamic process. Its not damage. Its dysregulation, but that could include epigenetic changes. That does not mean that some critical tissues are not damaged, only that ME can get worse or better dynamically, regardless of damage, in at least some cases. I have...

To illustrate this point, over a decade ago I was trying to get on a bus. The driver was saying things, possibly because I was having trouble with the new ticket system. I had no idea what he was saying. So he said it louder, thinking I was deaf. After a couple of tries he started enunciating...

I chose cognitive impairment, but PEM worsens cognitive impairment if I try to do too much. Nearly everything I need or want to do requires at least moderate cognitive capacity. So its the most disabling, affecting even physical tasks either directly or indirectly. In the early 80s I would have...

One of the theories behind why saunas might help ME, going back to the 90s, is that an autonomic jolt as temperature changes (but jumping in a pool after a sauna when you have ME might be very dangerous) might assist the brain to adapt. Its an old theory, and I am not sure its right.

There is a claim, and I have not looked into it, that black pepper increases the bioavailability of turmeric. Turmeric is the spice curcumin comes from. This might explain why black pepper is being added to curcumin supplements.

Dealing with this in our understanding has been my dominant thinking for years. Shifts in biochemical regulation are potentially as damaging as gross structural changes. I have been calling these biochemical lesions. Of course I have my own biases being a biochemist trained in systems theory.

... and the repeat test?

I suspect this is correct, but also a good break in activity in the middle can also short circuit PEM in some cases. I do think its a threshold, and the idea is that if we operate below that we do not crash. Its also a threshold in that the further we go over our limit the harder we crash. Of...

I have had this problem for the last several years. I am hoping my cataract surgery reverses this, but I think its unlikely. I need a stick for balance, an extra signal as to where the ground is.

I am very interested in explaining temporary remissions, including rapid declines and improvements. These took hours in my case. ME in at least some of us is an active process, or is modified by active processes. However we do not know if this applies to all ME patients or just a subgroup.

This might be correct, or not. Its not just POTS. Its also NMH, which induces bradycardia not tachycardia, or at least it did with me. Then there is the sudden drop of blood pressure in the brain without peripheral blood pressure loss which was discovered several years ago, and is not detected...

ME might be a single disorder, multiple disorders, multiple overlapping disorders, or a spectrum disorder. Models may look different in each case. Most of what I saw here I would class as either desirable or highly desirable features of a model of ME. Its less clear as to which are essential...

Wasn't there a study that showed that one group were able to do the extra exercise, but when activity data was studied it showed they were much less active, they gave up everything else to exercise?

Here is an example, though I have seen much better lists over the years - https://www.drugs.com/article/low-salicylate-diet.html Avoiding the very high salicylates might be useful, but my personal experience is avoiding nearly all might mean if I accidentally contact or eat them I have a much...

If there is a Th2 skew, and it turns out to be important, and replicable, then there are ways to treat that, including Th1 vaccinations. Its all too speculative at this point but its worth a longer look I think. I have still to read most of this and probably wont this month.

I have a breathing problem I treat with a herbal PDE4 inhibitor that raises cAMP. This goal has a wide application. It works well on my bronchospasms. I have been unable to experience any benefit for ME though.

Wont be reading these just now but I hope this is a sign more treatments might be tested.

Ditto.

On sleep quality, I found resveratrol made me sleep a fair bit less. However, my capacity to tolerate sleep deprivation improved a lot. I think the problem we have with tolerating drugs, and some chemicals, applies to just about all dietary intake though with large variation between patients...