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How fitbit data matches with symptom scores will be interesting. For the record I was using symptom scores to titrate treatments, in a clinic, in 1993. These were used regularly, but objective measures were determined from time to time.

So far this model does not even remotely capture PEM from what I can see. Its another chronic fatigue model. I hope I am wrong. PS ... unless they are not working on learned helplessness as a model.

Precisely.

I have long considered that meta-analysis can reinforce problems if there are systemic methodological biases in a field. CBT/GET comes to mind.

Except that it can be filtered out, apparently. I would like to see something on this formally published so we can check the details.

On a large blood protein, while it might result in signal, it might not be a signalling molecule. There might be sensors that detect it and react, such as if its a foreign protein or abnormal. It might even hide from investigation as its misfolded, and the absolute numbers or concentrations...

If its an unidentified substance then we simple do not know. However absolute amounts in, for example, the peripheral blood might not be very important. This is because local concentrations might be quite high(or low) in some places. Also timing is important. The timing of release of a factor...

At one point, several decades back, they were discovering a new hormone every year. Its important to distinguish between endocrine, exocrine, autocrine and paracrine hormones, but I think a new category was proposed too. That list of 50 is also deceptive, because at least some of the categories...

Here in Australia the right to record medical interviews varies state by state, its important to check your own state's law.

Something that activates IDO1 may be trialed at some point, at least in vitro. The problem with IDO2 only arises when the kinetics of IDO1 become poor. The issue here though is that the kinetics must be enhanced at high concentrations of tryptophan, and I doubt any of the drugs have been tested...

Yes, he repeatedly showed most doctors have a poor grasp of statistics in the USA.

I wrote a satirical blog on psychiatry as shamanism on Phoenix Rising, some years ago.

As you know there is no objective diagnostic test. Its mythical, supported by convincing rhetoric, with a total lack of evidence and usually unsound reasoning. I could make the same claims to causation but claim its invisible pink fluffy unicorns doing it. No evidence for that either. Gosh, does...

Is it time to translate and update the Hammer of Witches? Saying that mass hysteria has an old history is just saying these events have an old history. The label may not represent any real world discrete clinical entity. Now we do know people can panic, and when panicking they can exaggerate...

Beware claims based on anecdotes. Anecdotes can be spot on, completely right, but the issue here is you have no way of being sure unless you know all the details in question. So when someone pushing pseudoscience asks around, and gets a hundreds positive reviews or anecdotes, you don't get to...

My take on this is they vacillate on this view, and retreat to the position I stated when pushed. They do not necessarily believe it though. I think they reason along the lines you discuss a lot of the time too, if not pushed. Their position is not consistent. However, they most definitely...

The problem is the brain has layers of adaptive architecture that is integral to the neuronal structure. Its dynamic, not static, in things like visual processing and many other parts of the brain. To make the software/hardware distinction you also have to adopt the view that hardware is the...

Classic line from a computer game. Something like, murder them, because reasons. (Borderlands 2)

Tryptophan external to the cells is not the major problem. In addition most cells in us will not be in the trap, or we would die.

Prevention is the only tip, but that is not only about preventing fainting, its about location. Be careful in places that are higher risk. Use an elevator rather than stairs if you can. Going down stairs should be safer than going up stairs, but has higher risk if you do faint. Get up slowly...