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Key Points Question Do middle-aged and older adults with obstructive sleep apnea (OSA) have increased risk of incident cerebral microbleeds (CMBs)? Findings In this cohort study of 1441 adults, participants with moderate to severe OSA had an associated increased risk of developing CMBs...

“We’re seeing GLP-1 drugs show tremendous promise across a wide range of conditions, including improving markers of body-wide and brain inflammation, which is common in long COVID,” says Eric Topol, executive vice president of Scripps Research and co-principal investigator of LoCITT. “Given the...

Eric Topol “We've just launched the first large, site-less (home, direct to participant) randomized trial for treatment of #LongCovid, testing tirzepatide (a GLP-1 drug) vs placebo. Please help spread the word https://scripps.edu/news-and-events/press-room/2025/20251030-moore-vogel-locitt.html”

I was in contact with one of responders and she said she had no contact with the other patients and Fluge asked them not to contact each other (this is mentioned in the paper, I believe).

So hopefully the fact that the pharmodynamics of the responses were relatively consistent in the Daratumumab pilot trial gives you more hope?

@leokitten very convincing data, but I am already a believer. I wonder if a response to Abilify et al. might be correlated with a response to the biological (mab) drugs. If yes, you could pre-screen patients inexpensively for 2 weeks. Responders could then be treated with Daratumumab with the...

Merged So this individual with Sjogrens & ME/CFS responded or is responding to Dara 5 months post injection. Fluge’s Dara study showed patients tended to respond at 2-3 months post first injection. So that’s a decent difference. Does that mean that we can’t really attribute this person’s...

Abstract Mitochondrial dysfunction and stem cell exhaustion contribute to age-related immune decline, yet clinical interventions targeting immune aging are lacking. Recently, we demonstrated that urolithin A (UA), a mitophagy inducer, expands T memory stem cells (TSCM) and naive T cells in mice...

Someone who took the time to look at the paper (unlike me) has pointed out the baseline IGG was low due to pretreatment.

But IGG did go down in Fluge et al.

https://pmc.ncbi.nlm.nih.gov/articles/PMC7271608/ In conclusion, our data show that daratumumab reduces the frequency of normal PC, which is reflected in reduced levels of polyclonal IgA, IgE and IgM upon initiation of daratumumab treatment. However, our data also demonstrate that a proportion...

The severe peer review this must have undergone…. Forget peer review… this should have been read by a non-peer with some common sense. 29 authors including 6 Francesca/o! Is it 6 Francescii?

Register here https://longcovid.scripps.edu/locitt-t/

https://www.scripps.edu/news-and-events/press-room/2025/20251030-moore-vogel-locitt.html LA JOLLA, CA—Scientists at the Scripps Research Translational Institute invite people with long COVID across the U.S. to join a remote clinical trial that is testing whether an existing FDA-approved...

I’d be a lot more concerned about how the treatment would be rolled out in poor developing countries than in the United Kingdom, which is a top 15 country in human development index. How does the treatment get “rolled out” in Sudan and the Central African Republic? This is an additional concern...

https://www.medpagetoday.com/meetingcoverage/acr/112990 WASHINGTON -- A drug in advanced development for myasthenia gravis also showed promise as a treatment for primary Sjögren's syndrome, a researcher reported here. Patients receiving the infusion drug, called nipocalimab, at 15 mg/kg every...

Merged post ------------------- First multiple sclerosis patient in the UK receives CAR T cell therapy in groundbreaking trial https://www.news-medical.net/news/20251024/First-multiple-sclerosis-patient-in-the-UK-receives-CAR-T-cell-therapy-in-groundbreaking-trial.aspx “A multiple sclerosis...

"This is genuinely paradigm-shifting 1-3% of patients diagnosed with (relatively) common diseases – atopic dermatitis, inflammatory bowel disease, and multiple sclerosis – actually have much rarer monogenic conditions, revealed by genome sequencing Given the obvious importance of a correct...

I’m also one of the few people on here who is fine with the chronic fatigue label. It is also much easier to pronounce than myalgic encephalomyelitis.