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  1. J

    A waking death—encephalitis lethargica

    https://open.substack.com/pub/healthchecksonhistory/p/a-waking-death?r=7y4i4&utm_medium=ios Mentions ME/CFS
  2. J

    The missing heritability question is now (mostly) answered

    https://theinfinitesimal.substack.com/p/the-missing-heritability-question?utm_campaign=post&showWelcomeOnShare=true
  3. J

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    Video from one of the trial patients in Norwegian—anyone can translate?
  4. J

    Pathogenic IgG from long COVID patients with neurological sequelae triggers sensitive but not cognitive impairments upon transfer into mice, 2025, Mig

    Pathogenic IgG from long COVID patients with neurological sequelae triggers sensitive but not cognitive impairments upon transfer into mice Abstract Approximately 30% of long COVID patients still experience neurological symptoms (brain fog, pain, chronic fatigue) more than 4 months after the...
  5. J

    Alpha-gal syndrome: Meat allergy linked to tick bites

    After a Mysterious Death, a Family’s Quest for Answers Leads to a Tick https://www.nytimes.com/2025/11/20/nyregion/jetblue-pilot-death-tick-alpha-gal.html?unlocked_article_code=1.2k8.3NoZ.ShC5Sv-ibO5O&smid=url-share
  6. J

    Trazodone changed the polysomnographic sleep architecture in insomnia disorder: a systematic review and meta-analysis, 2022, Zheng et al

    But the physicians say no. https://www.aafp.org/pubs/afp/issues/2023/0200/fpin-ci-trazodone-insomnia.html
  7. J

    Trazodone for Insomnia

    So why did you stop taking it?
  8. J

    Trazodone for Insomnia

    https://www.aafp.org/pubs/afp/issues/2023/0200/fpin-ci-trazodone-insomnia.html
  9. J

    Trazodone changed the polysomnographic sleep architecture in insomnia disorder: a systematic review and meta-analysis, 2022, Zheng et al

    AI summary Here’s a much simpler, plain-language explanation of that whole passage: Researchers wanted to understand how trazodone, a medication often used off-label to help people sleep, affects the structure of sleep when measured by a sleep study (polysomnography) in people with insomnia...
  10. J

    Trazodone changed the polysomnographic sleep architecture in insomnia disorder: a systematic review and meta-analysis, 2022, Zheng et al

    Trazodone changed the polysomnographic sleep architecture in insomnia disorder: a systematic review and meta-analysis Abstract Trazodone has been widely prescribed for off-label use as a sleep aid. Identifying how trazodone impacts the performance of polysomnographic sleep architecture in...
  11. J

    Daratumumab, isatuximab (CD38 drugs)

    Ok but anecdotally and maybe in the literature also they say there are less adverse reactions to sub Q.
  12. J

    Efficacy and safety of allogeneic CD19 CAR NK-cell therapy in systemic lupus erythematosus: a case series in China 2025 GAO et al

    Summary Background Lately, autologous CD19-targeting chimeric antigen receptor (CAR) T cells have shown excellent efficacy in treatment of autoimmune diseases, but with great safety concerns, such as infections. In this study, we aimed to evaluate the safety, tolerability, and efficacy of...
  13. J

    Daratumumab, isatuximab (CD38 drugs)

    Hi @melihtas Long time no post—hope you are doing OK. “You have hit on a crucial physiological reality that separates simplistic biochemical theory from the complexity of human illness. You are absolutely correct: if the mechanism were only about plugging the "NAD+ leak," patients receiving...
  14. J

    Viral infections and the risk of neurodegenerative diseases: a comprehensive meta-analysis and systematic review, 2025, Liu et al

    Viral infections and the risk of neurodegenerative diseases: a comprehensive meta-analysis and systematic review, 2025, Liu et al Viral infections and the risk of neurodegenerative diseases: a comprehensive meta-analysis and systematic review Abstract Background Viral infections have been...
  15. J

    Germany's "National Decade Against Post-Infectious Diseases"

    Also this post indicates the anti-CD 19 trial wasn’t approved, I think. Post in thread 'News from Germany' https://www.s4me.info/threads/news-from-germany.11006/post-654322
  16. J

    Germany's "National Decade Against Post-Infectious Diseases"

    Why are they testing another anti-cd20 mab (ublituximab) when rituximab didn’t work? @Jonathan Edwards does this make any sense?
  17. J

    Alpha-gal syndrome: Meat allergy linked to tick bites

    Merged thread ------------------- https://abcnews.go.com/Health/new-jersey-man-believed-1st-death-red-meat/story?id=127524339 The man died in September 2024 just hours after consuming a hamburger.
  18. J

    Viewpoint | linking long Covid and AD(H)D through neuroimmune dysfunction: A translational framework proposal for precision medicine 2026 Spanoghe et

    Introduction, not abstract Introduction Few medical conditions in recent memory have generated as intense a research focus in merely five years as Long Covid (LC)—a post-acute infection syndrome. Major investigations have explored etiologies, candidate biomarkers and physiological mechanisms...
  19. J

    Portugal: 2025 International Conference on Clinical and Scientific Advances in ME/CFS and Long COVID

    Watching the Portuguese ME & LC conference...... is there any other group of major, life-destroying illnesses where longstanding clinicians in the field present on yoga asanas?
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