Abstract
The inflammatory reflex, in which vagus nerve signaling modulates cytokine production, is dysregulated in rheumatoid arthritis (RA). RESET-RA, a pivotal, double-blind, randomized, sham-controlled trial, evaluated a vagus nerve-targeted neuromodulation system for RA in 242 patients with...
Natural killer (NK) cells are cytotoxic and cytokine-producing innate lymphocytes with established roles in antiviral and antitumor immunity. In recent years, the biology of NK cells has been exploited in innovative cancer immunotherapies, leading to clinical advances including allogeneic NK...
Also another practical issue is that if you call the disease ME it makes it really difficult to do google/database searches because “me” is a top 10 word in the English language.
MZ—“minimally zippy” or “missing zest”, however, would be fine.
Abstract
BACKGROUND
In a phase 1–2 trial, teclistamab, a bispecific antibody targeting CD3 on T-cell surfaces and B-cell maturation antigen on myeloma cells, showed durable responses in heavily pretreated patients with relapsed or refractory multiple myeloma. Daratumumab, a monoclonal antibody...
@Jonathan Edwards
Do you have any idea why IGG levels didn’t decrease after the three additional Daratumumab shots (please see post 406 above).
I think this paper is saying that IGG doesn’t decrease after a certain point.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7271608/
If that is the case...
For the seven shot cohort, IGG didn’t decrease with the 3 additional shots (the yellow arrows). Any ideas about this? Maybe Daratumumab can’t deplete any more cells without NK cells?
I think the article could have been shortened by half or two thirds.
Wish there had been more discussion about Encephalitis lethargica, which may be a disease closely related to ME/CFS.
Also does anyone really need 50 years of psychoanalysis? Maybe the psychiatrist could have pulled the plug...
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