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Abstract Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer’s disease (AD), with recent proteomic studies highlighting disrupted glial metabolism in AD. We report that inhibition of indoleamine-2,3-dioxygenase 1 (IDO1), which metabolizes tryptophan to kynurenine (KYN)...

Switching off Autoimmunity https://www.science.org/doi/10.1126/science.ade6949

Dear @Jonathan Edwards If you can please suspend your skepticism regarding cyclophosphamide for a moment, and accept and that some patients did in fact have a response, why do think that Rekeland/Fluge found that the cyclo responders had significantly lower IGG levels at baseline (please see...

Maybe/probably Lipkins group at Columbia probably OK Unutmaz (Jackson) probably underwhelming—they had a recent AI paper tho—some people liked it. Hansen (Cornell)—don’t agree with her recent pronouncements about ME/CFS only being caused by an enterovirus and that it’s completely different...

Tirzepatide cuts risk of diabetes by 94% in adults with prediabetes and obesity or overweight, drugmaker says https://www.cnn.com/2024/08/20/health/tirzepatide-diabetes-lilly-trial/index.html...

Opposite the Ron Davis group finding re BH4, correct?

That’s a fair criticism. I should have defined significant to be less rigorous. But I also definitely wanted to kick out “research” such as all this Al-Aly nonsense where he is producing dozens of useless papers and is promoting himself as a “Long Covid Ally”.

I voted no, but maybe the Dutch researchers Lutter & Wust have made useful contributions.

Do you think that any Long Covid researchers have made any significant findings about ME/CFS? By Long Covid researchers I’m referring to researchers who joined the field since the Covid pandemic. Significant findings would include identifying the underlying causes of ME/CFS and identifying...

A Virtuoso Cellist’s Painstaking Path From Long Covid Back to the Stage Of course Pam Belluck doesn’t mention ME/CFS. https://www.nytimes.com/2024/08/17/health/long-covid-cellist.html?unlocked_article_code=1.D04.upJJ.iGInMUpg5DhO&smid=url-share

c'est des conneries

I registered but I think I said no to adding my name to the public list. I didn’t know it was possible to attend in person, but that option is closed now.

OK but I still recommend that people read the article by Scott Alexander that I posted in the original post. He speculates about how these drugs may affect the immune system—might possibly be relevant to MECFS.

I’m sure they could all get a FND diagnosis—that would explain everything (yes, sarcasm).

Multistep nominative determinism: 1. GLP-1RAs are being investigated as a way to suppress alcoholism 2. GLP-1RAs are based on a chemical found in Gila monster venom 3. Gila monsters were first described by zoologist Edward Drinker Cope en.wikipedia.org Edward Drinker Ha!

Article: Why Does Ozempic Cure All Diseases? https://www.astralcodexten.com/p/why-does-ozempic-cure-all-diseases?utm_campaign=post&triedRedirect=true I believe that @leokitten has had some relief from MECFS at higher doses of Zepbound.

They All Got Mysterious Brain Diseases. They’re Fighting to Learn Why. https://www.nytimes.com/2024/08/14/magazine/canada-brain-disease-dementia.html?unlocked_article_code=1.DE4.z8pQ.YfX4w54kidrC&smid=url-share

His son, Whitney.

Ron sounds a bit tired in this video but also optimistic. It’s worth watching.

AI summary of above video Summary of #IIMEC16 14 Ron Davis 16th Invest in ME Research International ME Conference 2024 This is an AI generated summary. There may be inaccuracies. · The green links below are Amazon affiliate links where summarize.tech may earn a commission. Summarize another...