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Makes one wonder if Multiple Myeloma patients could get away with fewer injections as well?? I’m guessing they want to be really really sure that they wipe out all the LLPCs in this case.

I’m assuming that they didn’t go with this revised protocol for the full Phase 2 study because they didn’t want to take the risk that weren’t fully depleting LLPC’s. With this very small sub-sample they could take the risk of doing fewer injections. FWIW, this is very different from the...

Here is the revised PILOT protocol. “Protocol ver. 1.6: Amended treatment protocol; this will apply to four additional patients included in Q1 2025, as well as retreatment of one previously included patient with partial relapse. Patients will receive the first daratumumab subcutaneous injection...

Two out of the three individuals mentioned here have no expertise in the “clinical and translational biology of LC and PVS”.

Mind if I ask how you were prescribed this medication? Isn’t it indicated for immunocompromised people as a Covid prophylaxis or treatment?

Background Fatigue is a common sequela of SARS-CoV-2 infection, with many COVID-19 patients subsequently developing chronic fatigue syndrome and myalgic encephalomyelitis (CFS/ME). Long-term associations between COVID-19, new-onset CFS/ME, and other independent predictors such as vaccination for...

Hmmm

Merged Scientist Dr Akiko Iwasaki joins SPEAR study group to investigate monoclonal antibodies for Long Covid and Covid-19 post-vaccination syndrome Press release—does anyone think this will work...

If anyone has interest/energy, if you sign up for a Medpage account, you can comment on the article. FWIW, I had no idea this guy was that bad when I posted.

If GLP-1 Drugs Are Good For Everything, Should We All Be on Them? https://www.derekthompson.org/p/why-does-it-seem-like-glp-1-drugs?utm_campaign=post&utm_medium=web

https://www.medpagetoday.com/opinion/second-opinions/116618 Of course, a simple Google search turns up the doc who wrote this opinion piece treats Long Covid related mitochondrial dysfunction with graded exercise therapy.

OK, trying to sort this out. Jeff’s affiliation on the paper is Renegade Research, which is a nonprofit. His email on the paper is jeff@mech*nicalbasis.org. He is listed on the Chiari EDS Center website, which doesn’t look like a nonprofit, with an email for the Mount Sinai hospital system...

A rare drug trial for long Covid failed, yielding lessons on study design BC 007, a German infusion that had lifted hope of patients, is heading for new study https://www.statnews.com/2025/07/22/long-covid-research-mistakes-to-fix/

Following infection with SARS-CoV-2, patients may experience with one or more symptoms that appear or persist over time. Neurological symptoms associated with long COVID include anxiety, depression, and memory impairment. However, the exact underlying mechanisms are not yet fully understood...

Math?

Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of various hematological malignancies. Recently, CAR-T has been used in refractory auto-immune diseases with initial encouraging results. In this systematic review, we examined the safety and efficacy of CAR-T in...

Cort Johnson article. In the comments there is one MECFS patient on Dara for MM, with no beneficial effects on MECFS symptoms. https://www.healthrising.org/blog/2025/07/18/b-cell-depleter-long-covid-daratumumab-chronic-fatigue/ ETA Cort highlights IgG4 because he has high IgG4.

https://www.wsj.com/health/chronic-lyme-disease-ticks-treatment-f075b588 Mentions “Long Covid” and fibromyalgia but of course not MECFS. Meh.

Essay by Invisible Kingdom Author Meghan O’Rouke “But in other aspects of life, A.I. surprised me. I asked it to write memos, draft job postings, create editorial checklists — even offer its opinion on the order of poems in an anthology I was assembling. Tasks I might otherwise have avoided or...

Summary Transformative neuropathology is redefining human brain research by integrating foundational descriptive pathology with advanced methodologies. These approaches, spanning multi-omics studies and machine learning applications, will drive discovery for the identification of biomarkers...