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    BCMA T-Cell Engager Therapy in Patients with Refractory Autoimmune Disease 2025 Bucci et al.

    If anyone has access to the full article, am interested in finding out when the positive response began (how many weeks after the first injection). Thanks.
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    BCMA T-Cell Engager Therapy in Patients with Refractory Autoimmune Disease 2025 Bucci et al.

    Popular article https://www.medpagetoday.com/rheumatology/generalrheumatology/117966
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    BCMA T-Cell Engager Therapy in Patients with Refractory Autoimmune Disease 2025 Bucci et al.

    Abstract Teclistamab, a T-cell engager targeting B-cell maturation antigen, showed promise as a rescue therapy in 10 patients with refractory autoimmune diseases and led to clinical and serologic improvements in most patients. Paywalled….full abstract...
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    News from Scandinavia

    I know this is an incredibly long shot, but does anyone know anyone who who lives in Stockholm who would give me a bed for a week or two while I'm supporting a member of our ME community? This is really important. I don't have a budget but have got money to get there. Please rt!
  5. J

    Do you have small fiber neuropathy (SFN)?

    SFN poll—in light of the discussion of SFN in the Sjogrens thread. If you have SFN but have a different different disease like fibromyalgia, it would be helpful to note this in the comments. https://en.wikipedia.org/wiki/Small_fiber_neuropathy
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    Daratumumab, isatuximab (CD38 drugs)

    Subcutaneous Isatuximab Delivery Is Noninferior to IV Administration in Multiple Myeloma https://www.onclive.com/view/subcutaneous-isatuximab-delivery-is-noninferior-to-iv-administration-in-multiple-myeloma
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    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    No, oral all-trans retinoic acid (ATRA) is not the same as vitamin A, but it is a derivative of vitamin A and belongs to the same class of compounds called retinoids. While vitamin A has many functions, ATRA is a more specific, active metabolite that is used as a medication to force immature...
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    Who will pursue treatments for low NK cell patients?

    By “hopefully a lot of other people as well” do you mean, for example, patients with fibromyalgia, post treatment Lyme, and idiopathic fatigue that doesn’t meet ME/CFS criteria?
  9. J

    Who will pursue treatments for low NK cell patients?

    Given the fact that the Fluge/Haukeland phase 2 Daratumumab trial will exclude patients with low NK cell #s, will anyone follow up on this group of patients? Or should Fluge’s group have included a couple of low NK cell patients who underwent “pre-treatment” for low NK cells, with things like...
  10. J

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    From AI Oral all-trans retinoic acid (ATRA), also known as tretinoin, is a potent chemotherapy agent used primarily to treat acute promyelocytic leukemia (APL). Unlike topical tretinoin, which treats acne, the oral form causes cancerous white blood cells to mature and die naturally. Oral ATRA...
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    A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging Chen 2025

    https://www.bbc.com/news/articles/cz7rxy21lxwo BBC article The animals are resistant to cancer, deterioration of the brain and spinal cord, and arthritis, so many scientists want to understand more about how their bodies work.
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    A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging Chen 2025

    Mole rats—living the good life Editor’s summary Somewhat lacking in good looks, the naked mole rat gets attention because it is very long lived and highly resistant to cancer. Chen et al. revealed a molecular mechanism that contributes to successful aging in these rodents: a change in the enzyme...
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    Closed Impact of Vagal Approaches on Symptomatology in Long COVID Participants [Remote]

    Survivor Corps is advocating with you to better understand COVID-19 and Long COVID through citizen science, research, legislation and policy. Calling All Citizen Scientists! Join a 4-week Study Exploring Wellness Products for Long COVID Symptoms. Join ASAP! We’re inviting individuals with...
  14. J

    Trial Report Plasma cell targeting with the anti-CD38 antibody daratumumab in ME/CFS -a clinical pilot study, 2025, Fluge et al

    NK cell count as predictor of clinical response in patients with rheumatoid arthritis treated with rituximab https://www.dovepress.com/nk-cell-count-as-predictor-of-clinical-response-in-patients-with-rheum-peer-reviewed-fulltext-article-BTT Same in RA @Jonathan Edwards
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    Nobel prize physiology/medicine 2025

    Nobel Prize winners discovered a new type of immune cells.And they didn't even do a single podcast debate with a comedian who didn't believe their findings....
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