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I agree, this is really misleading, even worse than the abstract of paper on the PRINCE Secondary trial. I've plotted the primary outcome Fatigue severity (FIS-40 questionnaire) below. Yet the authors write: "Overall, these findings support the use of CoQ10 plus NADH supplementation as a...

More info and background about the study here: https://www.npr.org/sections/health-shots/2021/07/28/1021888033/breakthrough-infections-may-cause-long-covid-symptoms-small-study-suggests and here:

An Israelian study in New England suggesting that some people who are vaccinated may still go on to have persistent symptoms after 6 weeks. The sample size was relatively small. Vaccines protect people really well from severe infection, but I really hope they will be equally effective at...

Merged thread Covid-19 Breakthrough Infections in Vaccinated Health Care Workers Abstract BACKGROUND Despite the high efficacy of the BNT162b2 messenger RNA vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), rare breakthrough infections have been reported, including...

The standard deviation for CK in the control group seems unusually large. It's reported as 282.88 while the mean is only 121.90. The standard deviation in the control group is only 34.43. It also doesn't fit with the relatively small confidence interval for the mean:

Seems that there is a small type in table 2. I think the mean difference for monocytes should be 0.039 rather than 0.39

The important thing is that research in the US, UK, and Norway are also eligible to receive funding under Horizon Europe

Twitter summary:

1) Had a quick look at new NIH grants for ME/CFS research in 2021. Seems like there are three new projects: One study at Stanford University is doing PET imaging using radiotracer [11C]DPA-713 for translocator protein 18 kDa (TSPO) which is an established imaging biomarker of inflammation...

I previously commented on their work, in relation to the CCI-saga, in this thread: https://www.s4me.info/threads/jen-brea-my-me-is-in-remission.9594/page-15#post-171079

The authors write: And: I don't see them offer a solution to these problems. It still doesn't make sense in my view. The authors on the other hand conclude:

Abstract Background Chronic Q fever usually develops within 2 years after primary infection with Coxiella burnetii. We determined the interval between acute Q fever and diagnosis of chronic infection, assessed what factors contribute to a longer interval, and evaluated the long-term follow-up...

I had the same impression. Haven't looked at it closely but I have a suspicion that the "hard science" Benedetti refers to (his own work presumably) is rather weak. I haven't seen anything yet that shows the placebo effect isn't simply due to response bias.

Interesting article highlighted by Nina Steinkopf in her blog: The Dangerous Side of Placebo Research: Is Hard Science Boosting Pseudoscience? - Benedetti - 2019 - Clinical Pharmacology & Therapeutics - Wiley Online Library

David and I have submitted a short commentary on the study. Not sure if it will get published, therefore we have also posted it as a preprint on OSF: https://osf.io/86bkz/

LL37 is the same as CAMP which was up in this Lipkin study. Someone suggested to me that it could be worth exploring in ME/CFS. It has been tested here: Treatment with LL-37 is safe and effective in enhancing healing of hard-to-heal venous leg ulcers: a randomized, placebo-controlled clinical...

Evelien and I wanted to get 1000 points but we didn't make it.