Something related: we wrote a short summary of the psychosomatic history of epilepsy. Doctors used to write terribly things about epilepsy patients, it felt like reading a racist pamflet filled with hatred.
https://mecfsskeptic.com/psychosomatic-history-of-epilepsy/
Seems like quite a problematic study. It only focuses on the effects of the clinician (e.g how it impacted their well-being) not on how the whole story impacted patients.
In fact, it seems that this study only captures the view of the clinicians (e.g. that the complaint was about loss of...
The authors used a Norwegian cohort of 70.000 people being followed up for a study on pregnancy during the pandemic. 774 (1.0%) got infected with the coronavirus. A COVID-19 diagnosis was obtained from registry data based on PCR confirmed SARS-CoV-2 infection. The researchers matched the...
This is not a new study, just noticed it on Twitter, but it's quite interesting and I think it deserves its own thread.
A good Twitter summary is available here:
Merged thread
ABSTRACT
Physical, psychological and cognitive symptoms have been reported as post-acute sequelae for COVID-19 patients but are also common in the general, uninfected population. We aimed to calculate the excess risk and identify patterns of 22 symptoms up to 12 months after...
Here's an archived version of the trial website, in case it gets deleted when the results are published: Moe na COVID-19? | Doe mee aan de ReCOVer studie (archive.org)
Apparently, one has to pay €1065 to submit a letter to the journal to point out some of the problems with this trial.
https://trialsjournal.biomedcentral.com/about
It's rather misleading that the title states this is a controlled randomised trial.
Patients in the control group receive no intervention from the researchers but only the standard medical care they manage to gather themselves from their treating physicians, GP or other therapists. So the care...
These Korean researchers modified the Chalder Fatigue Scale because the comparison to "as usual" was confusing. The authors write:
"To resolve the difficulty of assessment based on the comparison with the “usual” status, the mKCFQ was adapted to a 10-point Likert scale (0= ‘not at all’ to 9=...
Thought this was an interesting study as it provides some interesting data regarding psychosomatic theories that disturbances of the mind cause physiological disease in the body.
The authors looked at soldiers who were discharged in 1944 for psychoneurosis to see if they hade higher mortality...
Abstract
World War II Army inductees medically discharged for psychoneurosis in 1944 experienced a 20-percent excess mortality over the period 1946-1969, highest in the earlier years and diminishing thereafter. Some of the differential mortality, e.g., from inflammatory diseases of the CNS...
Hi, is there anyone who can help me getting the full text of this article:
https://pep-web.org/browse/document/psar.042.0217a
It's an old article from a psychoanalytic journal (The Psychoanalytic review) that is not included in some databases and where a yearly subscription costs more 1000...
main results:
"Post-hoc tests of the total sample indicated that individuals with somatic symptom disorder had significantly lower hair cortisol concentrations than healthy controls and individuals with a functional somatic syndrome (both p < .012), whereas there was no difference between...
Just had a look and this 2019 paper by Younger found higher levels of myo-inositol (compared to creatine in the Right Palladium) while this paper reports lower levels (compared to water or N-acetylaspartate in the anterior cingulate cortex).
Had another look at the results.
Nakatomi et al. reported huge differences in BPND of [11C]-PK11195 between ME/CFS and controls, for example an effect size of 2.4 standard deviations for the midbrain. In all brain regions, ME/CFS patients had much higher values.
In the study by Raijmakers et...
Thanks for asking these questions, very useful.
During the Massachusetts ME/CFS conference Lipkin said their findings were confirmed by a Japanese group. I assume he was referring to this paper by Sato et al. Skewing of the B cell receptor repertoire in myalgic encephalomyelitis/chronic fatigue...
This first call is mainly focused on developing a patient registration and biobank. Everything looks ok, collaboration with patient representatives is an important criterium. Hope there were will be some good applications.
The full text of the call is available (in Dutch) here...
The NYT article is good. It revolves around Chris Maher, a professor at the University of Sydney’s School of Public Health, who makes similar arguments as you.
Maher recently published an article about this:
Placebos in clinical care: a suggestion beyond the evidence | The Medical Journal of...
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