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  1. ME/CFS Science Blog

    Complaints from patients with [FND]s: a cross-sectional UK survey of why patients complain and the effect on the clinicians..., 2018, Bolton

    Something related: we wrote a short summary of the psychosomatic history of epilepsy. Doctors used to write terribly things about epilepsy patients, it felt like reading a racist pamflet filled with hatred. https://mecfsskeptic.com/psychosomatic-history-of-epilepsy/
  2. ME/CFS Science Blog

    Complaints from patients with [FND]s: a cross-sectional UK survey of why patients complain and the effect on the clinicians..., 2018, Bolton

    Seems like quite a problematic study. It only focuses on the effects of the clinician (e.g how it impacted their well-being) not on how the whole story impacted patients. In fact, it seems that this study only captures the view of the clinicians (e.g. that the complaint was about loss of...
  3. ME/CFS Science Blog

    (Preprint) Excess risk and clusters of symptoms after COVID-19 in a large Norwegian cohort by Caspersen et al.

    The authors used a Norwegian cohort of 70.000 people being followed up for a study on pregnancy during the pandemic. 774 (1.0%) got infected with the coronavirus. A COVID-19 diagnosis was obtained from registry data based on PCR confirmed SARS-CoV-2 infection. The researchers matched the...
  4. ME/CFS Science Blog

    (Preprint) Excess risk and clusters of symptoms after COVID-19 in a large Norwegian cohort by Caspersen et al.

    This is not a new study, just noticed it on Twitter, but it's quite interesting and I think it deserves its own thread. A good Twitter summary is available here:
  5. ME/CFS Science Blog

    (Preprint) Excess risk and clusters of symptoms after COVID-19 in a large Norwegian cohort by Caspersen et al.

    Merged thread ABSTRACT Physical, psychological and cognitive symptoms have been reported as post-acute sequelae for COVID-19 patients but are also common in the general, uninfected population. We aimed to calculate the excess risk and identify patterns of 22 symptoms up to 12 months after...
  6. ME/CFS Science Blog

    Protocol ReCOVer: A RCT testing the efficacy of CBT for preventing chronic post-infectious fatigue among patients diagnosed with COVID-19.

    Here's an archived version of the trial website, in case it gets deleted when the results are published: Moe na COVID-19? | Doe mee aan de ReCOVer studie (archive.org)
  7. ME/CFS Science Blog

    Protocol ReCOVer: A RCT testing the efficacy of CBT for preventing chronic post-infectious fatigue among patients diagnosed with COVID-19.

    Apparently, one has to pay €1065 to submit a letter to the journal to point out some of the problems with this trial. https://trialsjournal.biomedcentral.com/about
  8. ME/CFS Science Blog

    Protocol ReCOVer: A RCT testing the efficacy of CBT for preventing chronic post-infectious fatigue among patients diagnosed with COVID-19.

    It's rather misleading that the title states this is a controlled randomised trial. Patients in the control group receive no intervention from the researchers but only the standard medical care they manage to gather themselves from their treating physicians, GP or other therapists. So the care...
  9. ME/CFS Science Blog

    Comparison of assessment scores for fatigue between multidimensional fatigue inventory (MFI-K) and modified chalder fatigue scale (mKCFQ), 2022, Lim

    These Korean researchers modified the Chalder Fatigue Scale because the comparison to "as usual" was confusing. The authors write: "To resolve the difficulty of assessment based on the comparison with the “usual” status, the mKCFQ was adapted to a 10-point Likert scale (0= ‘not at all’ to 9=...
  10. ME/CFS Science Blog

    EU: News from the European ME Coalition (EMEC)

    An extensive summary of that meeting can be found here: https://europeanmecoalition.com/summary-of-the-peti-meeting-on-the-me-cfs-petition/.
  11. ME/CFS Science Blog

    EU: News from the European ME Coalition (EMEC)

    @Adam pwme from Broken Battery has made this excellent video with highlights from the most recent discussion of ME/CFS in the European parliament.
  12. ME/CFS Science Blog

    Twenty-four Year Mortality Follow-up of Army Veterans with Disability Separations for Psychoneurosis in 1944, Keehn et al., 1974

    Thought this was an interesting study as it provides some interesting data regarding psychosomatic theories that disturbances of the mind cause physiological disease in the body. The authors looked at soldiers who were discharged in 1944 for psychoneurosis to see if they hade higher mortality...
  13. ME/CFS Science Blog

    Twenty-four Year Mortality Follow-up of Army Veterans with Disability Separations for Psychoneurosis in 1944, Keehn et al., 1974

    Abstract World War II Army inductees medically discharged for psychoneurosis in 1944 experienced a 20-percent excess mortality over the period 1946-1969, highest in the earlier years and diminishing thereafter. Some of the differential mortality, e.g., from inflammatory diseases of the CNS...
  14. ME/CFS Science Blog

    Help finding article: Kowal. 1955. Emotions As a Cause of Cancer: 18th and 19th Century Contributions

    Hi, is there anyone who can help me getting the full text of this article: https://pep-web.org/browse/document/psar.042.0217a It's an old article from a psychoanalytic journal (The Psychoanalytic review) that is not included in some databases and where a yearly subscription costs more 1000...
  15. ME/CFS Science Blog

    Hair cortisol levels in women with medically unexplained symptoms (2021) Fischer et al

    main results: "Post-hoc tests of the total sample indicated that individuals with somatic symptom disorder had significantly lower hair cortisol concentrations than healthy controls and individuals with a functional somatic syndrome (both p < .012), whereas there was no difference between...
  16. ME/CFS Science Blog

    Neurochemical abnormalities in chronic fatigue syndrome: a pilot magnetic resonance spectroscopy study at 7 Tesla, 2021, Godlewska et al

    Just had a look and this 2019 paper by Younger found higher levels of myo-inositol (compared to creatine in the Right Palladium) while this paper reports lower levels (compared to water or N-acetylaspartate in the anterior cingulate cortex).
  17. ME/CFS Science Blog

    No signs of neuroinflammation in women with [CFS] or Q fever fatigue syndrome using the TSPO ligand [11C]-PK11195, 2021, Raijmakers, Knoop et al

    Had another look at the results. Nakatomi et al. reported huge differences in BPND of [11C]-PK11195 between ME/CFS and controls, for example an effect size of 2.4 standard deviations for the midbrain. In all brain regions, ME/CFS patients had much higher values. In the study by Raijmakers et...
  18. ME/CFS Science Blog

    Plasma proteomic profiling suggests an association between antigen driven clonal B cell expansion and ME/CFS, 2020, Lipkin et al

    Thanks for asking these questions, very useful. During the Massachusetts ME/CFS conference Lipkin said their findings were confirmed by a Japanese group. I assume he was referring to this paper by Sato et al. Skewing of the B cell receptor repertoire in myalgic encephalomyelitis/chronic fatigue...
  19. ME/CFS Science Blog

    The Netherlands - €28.5 million ME/CFS research program - ZonMW funding awards announced April 2023

    This first call is mainly focused on developing a patient registration and biobank. Everything looks ok, collaboration with patient representatives is an important criterium. Hope there were will be some good applications. The full text of the call is available (in Dutch) here...
  20. ME/CFS Science Blog

    Placebos in clinical care: a suggestion beyond the evidence, 2021, Maher et al

    The NYT article is good. It revolves around Chris Maher, a professor at the University of Sydney’s School of Public Health, who makes similar arguments as you. Maher recently published an article about this: Placebos in clinical care: a suggestion beyond the evidence | The Medical Journal of...
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