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Increased ROS in the gut can impair the gut barrier, I wonder if increased ROS in the blood can do so with the blood/brain barrier, then stuff that's not supposed to get into the brain could cause additional problems.

A problem is that many learn that this just simply doesn't happen (okay, I can't speak for all but in Norway doctors learn very little about nutrition and food, and us dieticians-to-be often get the story this does not happen). As an example, if you don't have celiac then you cannot have a...

It's even mentioned in the report from how the research council felt the project went. Not the skewed media coverage (sadly), but that there were tensions between the "BPS and the purely biological camps". They also discuss some of the things you bring up @Peter Trewhitt

'BehovME' was a pilot project in Norway for something like this, where patients had a say in what research got funded.

He does seem to have some specific studies in mind with those examples, including one from UiO, that's good :)

My thoughts as well. I wonder if fragrance oils could be used instead.

I found a sister paper in "Music and Medicine" http://mmd.iammonline.com/index.php/musmed/article/view/679/0 Full text only available to subscribers. Edit: Please note that this study was part of a randomized controlled trial ;)

Another thing about this paper that has been bugging me lately is that it says in the protocol that the study sets out to research the youths that quote: actually did develop CFS 6 months after the acute EBV infection. All the preliminary titles on clinicaltrials.gov, REK, the treatment manual...

I can't believe I missed that. Thanks :) @Invisible Woman put it quite nicely.

What is she referencing with Ioannidis and COVID-19? I've not considered him a hero, he's written about the problems in the nutrition field which has been nice, but at the same time he had accepted some of the bad evidence from the science he was criticising and to me it came out a bit weird.

I am seriously worried about this. I got sick before 26 years of age and haven't been able to work. As of now I'm able to study, but the years I wasn't has put me behind my age-mates and thus my studies has yet to enable me to make any income.

And a change in tight junction proteins which could reduce intestinal integrity and increase the immune system's contact with allergens.

Has anyone heard about this "CBT for CFS" study at NTNU? https://app.cristin.no/projects/show.jsf?id=2063494 English translation of the pop sciency summary: I found this one: "Is cognitive behavior therapy a good treatment for chronic fatigue syndrome?" that might be the same project. It says...

Yes. But the problem comes when you throw ME into the mix. Is digestion too much of an exertion for the pwME in the study? Will they even screen for that? If I'm on the end of my limit a meal can cause me to crash (and the macros of the meal might be important, how digestable the food is...

All the potential and then this? Food and cognition is interesting, but I'd be more interested in long term effects.

The worst is I did not think about the obvious pun when I wrote it :facepalm::laugh:

This. And it's so sad :(

I agree, DecodeME is going to be fascinating! Glutamate, glutathione, cysteine and mitochondria is very interesting as well, especially for a nutritionist/cell biologist :D

But glutamate is not very specific. It can also be affected by lifestyle factors like diet and activity levels. Excitotoxicity is also linked to suicide ideation, psychosis, major depression, autism, I guess cognitive impairment (can't remember) and the whole glutamine/glutamate relationship and...

This makes me happy :) Well done everyone involved!