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I think 15 is enough to show a difference of clinical importance. At least it looks as if it is perfectly possible to have PEM as a symptom without finding a major dip at day 2. That doesn't worry me particularly. I think the link between the two would have to be indirect anyway.

I agree with Hutan that it would be nice to think that but the other speakers were generally not very convincing medically. The BPS approach is not going to be rebutted by shaky science. Winning the argument in the public eye is all very well but if the medical profession is unconvinced things...

I have sent it in for publishing. People are welcome to comment on Qeios as 'peer review' but I am not intending to modify the text further unless there is a reason to make a major content change.

It is of interest but I will be in Peru and I suspect I am not invited anyway. It is interesting to see the range of people involved including Helen Baxter and Sue Luscombe, together with AG from UCLH and also MS from the homeopathic hospital. She seems to be in to Yoga (for those who haven't...

This trial was getting going in 2014. I never caught up with the publication. But at the time I thought Newton's argument that if rituximab worked for fatigue in one illness it ought to work in others was weak. Primary biliary cirrhosis is obviously antibody mediated. So its manifestations...

'Improving signs of T cell exhaustion' sounds an awful lot like a wing and a prayer to me.

Does anyone know whether there is any serious scientific hypothesis behind this? My limited knowledge of rapamycin is that it suppresses immune responses. I do not see the logic of choosing a single low dose. A dose ranging study might make sense but giving a low dose of an immune modulating...

Can I ask what you are meaning by MCAS, @Arisoned ? My understanding is that MCAS is supposed to be a term for presumed mast cell activation that is not allergen related - i.e. not standard allergy. I am also unclear as to quite what symptoms it is supposed to have. I think allergy to alcohol...

symptoms I realise that it is a bit vague but it is the difficulty of defining or predicting the time course that I see as important.

Thanks Andy. The majority said yes. I will be interested to see how many for each sort of reason. The general discussion seems to have stopped 5 years ago but clearly worth a re-read. Edit: yes, well worth a read, lots of information, but it would be nice to have an option poll to clarify...

That isn't a satisfactory answer Sasha. Or maybe I should put in another alternative: I've been avoiding alcohol for so long now that I can't remember the symptoms that led me to avoid it.

This thread is to gather information on people's alcohol intolerance and discuss the implications.

Yes, OK, if I can remember how to do that.

I certainly think that there may be a completely ne layer of problems for the severe/VS. What I would look for are clues that quite different symptoms might be versions of the same thing (as turned out in RA) or versions of one symptom that turn out to be quite different things. I thin we...

OK guys, Qeios have reminded me that I need an abstract. So I have added one. I have also re-checked the full stops in the references! Final comments on the abstract welcome. Hopefully it can be uploaded by Friday.

Exactly. They seem to be ignoring the fact that even according to psychologists there are about six completely different ways in which psychosocial states might impact presentation of symptoms - including the one from the overweight psychiatrist who said ME/CFS was middle aged women frustrated...

The effort of sorting out the nine lesions in RA consisted merely of me lying on a sofa for 2 hours and pondering many hundreds of times over a twenty year period!! And some reading of Bywaters and Gardiner. The forum is an ideal place to get lots of people lying on sofas thinking. They should...

Things are an order of magnitude more difficult, it might seem. But science is always about solving a problem that is an order of magnitude more difficult than the last one, except that the difficulty remains much the same because you can benefit from what you learnt last time and technological...

I wouldn't dismiss @Sasha's suggestion, @Simon M. It took me twenty years to work out the critical steps in rheumatoid and the solution was driven by very detailed clinical observation. The clincher was that I had gradually whittled down the pathology of RA to nine specific and apparently...

There are some significant differences there. Altmann is talking of LC proposals that might include ME/CFS I suspect. Almost everything that could be measured in ME/CFS has been measures and found normal. There may well be room to measure some of these things for the first time in LC but the...