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Yes, it is only relevant to malignant cells that lose CD38 by mutating and thereby become 'invisible'.

I think there may be a problem with using skin biopsies for diagnosing SFN. As I understand it the number of small nerve fibres is counted. Whether it is really possible together a reliable number out or not I don't know. I would expect the method to be very open to subjective bias. I would...

That is probably about all we have. If there is no sign of something like an adrenaline secreting tumour or a dangerous heart rhythm then waiting and hoping may be the best plan. Obviously I cannot say anything specific about anyone's particular case but very often in this situation more...

I think the problem is that for the tests we have it is not clear what to make of the answers and nobody knows what other tests to think up. An awful lot has to be known in order to be able to use a test to reliably explain a pattern of symptoms. It is not so much that nobody is bothered but...

Yes, but that could mean any number of things. It is also not clear whether it means that the fault is in the autonomic system itself or something else that regulates it. To me this is too vague a term to be of any clinical use.

I agree with @Hutan that this is a potentially valid way of doing a study. But there is a potential problem that they will not know whether the treatment made one group better or the other group worse - quite apart from safety in terms of other unwanted effects. If the trial generated a...

Something that I don't actually know, despite having been a co-author of a Cochrane Review, is whether or not Cochrane Reviews actually cost Cochrane anything to get done. I don't remember my senior author getting funding from Cochrane but she may have done. My impression was that people...

As a physician I am not at all sure what 'dysautonomia' is supposed to mean. I mostly hear the word being used by colleagues whose scientific understanding I doubt. Traditionally, it has been associated with rare syndromes where there is generalised failure of autonomic nerves but that does not...

I am not sure I understand what was being looked for here and why. CSF might give an indication of what brain might have been doing but the samples were taken before and after physical exercise with arms and legs I presume.

Well, as Hutan points out there is huge scope for harm - and since the amount of harm is unknown it is completely unethical to behave that way in routine practice without getting some reliable trial data. The longer I life the more sure I am that psychological approaches cause massive...

Spot on.

Another Guardian piece, this time on shortage of physiotherapists for children. Maybe some are badly needed but maybe someone needs to check whether the treatment does anything useful...

Sorry David, I posted a tidied up version of the letter without the title by pasting from Word. The title is “Advocates of the intervention launched a full-on bid to try to stop the project. “ which gives you the meaning of the bit in parenthesis.

So when does hardware become firmware or software? Looking back at the old BBC-B computers with software chips it is all rather unclear. Neural circuits can be trained but I am not sure there is evidence they can be de-trained. You just overwrite some further training. There are instances of...

Is there any evidence for amalgams causing a problem?

I don't think BMJ will run it because I mention a name - Chalmers - and that is not allowed. So by all means post it. The version sent was: Dear Editor, Your 27th January News article by Jacqui Wise (2025) gives a fair account of the disgraceful behaviour at Cochrane over the abandonment of...

And that is an anecdote @dave30th ;). Remember when Michael Buchanan came back to us and said that an eminent Cambridge statistician thought PACE was not too bad - so the deal's off? (Another anecdote.)

OK, so we probably agree roughly on that. But why is it 'software', since it is going to be neuronal microstructure presumably that mediates response patterns - I don't mind but it gives the impression of some sort of understanding I am not sure we have. And maladaptive motor response sounds...

Yes, that is why we test drugs on rats and if they work on rats we test them on humans. But the analogies need to be realistic. The sets and subsets have to be relevant to what is being studied. Where there are obvious differences in members of a set then confidence changes but the most...

It looks like it has gravitated to 'activity management' = GET. I am sorry that I was not of more use here.