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No, I've been keeping a weather eye open. I suppose it's possible they did make a decision by end 2018, but just not got around to publishing it yet. Maybe.

Hardly surprising, given that Wessely's behaviour always comes across as that of a highly ambitious political animal first and foremost, with everything else secondary to that. I doubt people reach such politically influential positions unless those in power are confident they are highly...

[My bold] I cannot claim to understand all the fine detail of this, but ... What was different about the first 3 at each centre? From the link you supplied, it seems clear that stratified randomisation relies on researchers understanding the implications of potential bias. But that could cut...

Clearly you are right, and is of course what I was saying. Such extrapolation is akin to convincing yourself a field is perfectly flat, and then presuming the earth is therefore flat also ... now where have I heard that before?

For a trial such as PACE what is the formal process for randomisation of participants, and how is it recorded and audited? At what stage is it done? Are the processes of recruitment and randomisation going on in parallel? Or can randomisation only be done once all participants have been...

I would have thought that if one looks at such things from a systems perspective, there will inevitably be very rare cases where the part of the system that develops a fault may be the mental processing part - which is a crucial part of the overall system. I think that statistically it is going...

This could be something where the big-data research approach might turn up a correlation or two to investigate further, maybe identifying some unexpected possibilities.

An interesting cautionary perspective here ... 5 "Don'ts" of Practicing Gratitude https://www.psychologytoday.com/gb/blog/between-you-and-me/201303/5-donts-practicing-gratitude?collection=152996

Excellent, as always. Given it was an Australian whose courage and determination has enabled so much progress over the last couple of years, wouldn't it be good if this Australian advisory committee could truly do right by PwME. Another chance to set a great example.

When a PwME hits this completely done in stage, it is presumably possible to test if there is any unused oxygen still available?

Do we know if PwME can safely exercise to their anaerobic threshold. Or might there be some other disease-specific threshold they may reach before that, with potential risk of harm if pushed further?

Many thanks.

Yes, if the study is well-intentioned then that is a great start. But it's crucial they understand that any normal monitoring for harms may not be adequate for PwME, given how many reports there are of PwME going from mild/moderate to severe from graded exercise programmes that supposedly...

From my position of medical ignorance, I'd assumed this was what happens with PwME anyway, on a routine basis. I remember reading maybe 10 years or so back, that a PwME effectively "hits the wall" much like a marathon runner does it, except that for the PwME it happens pretty much every day...

Is this it? http://www.margaretwilliams.me/2013/role-of-science-media-centre-and-insurance-industry.pdf "Section 4: The SMC’s campaign against ME/CFS patients" This is accessible from MEpedia's page (ref 98) ... https://me-pedia.org/wiki/PACE_trial#Prof_Malcolm_Hooper.27s_complaints

And yet penetratingly blunt.

Yes. A bit like asking people how yellow something is.

A fundamental problem surely is that with such questionnaires the signal-to-noise ratio is appallingly low. The noise level is going to be very high, whilst many of the signals being supposedly acquired will sit well within the noise. And the noise is nothing like random.

Indeed, it is an excellent example of one of the more destructive forms of positive feedback, where something goes into "runaway mode", recursively feeding on itself rather than on anything independently grounded. I would think like a lead balloon in some quarters ;)

Wow - @Brian Hughes is not backwards in coming forwards is he! Well done Brian :).