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  1. Snow Leopard

    US Senate passes historic resolution on ME/CFS

    Governments pass hundreds of resolutions like this without taking action. Show us the money (policy that increases research capacity), don't just pretend to care!
  2. Snow Leopard

    Beware creating a moral panic about antivaxxers Fiona Fox The Times 2019

    There is very strong evidence that vaccinations work. The evidence is simple, compare the rates of child mortality due to vaccine preventable illnesses over time as vaccine schedules were adopted and improved. There are risks of course, specifically rare cases of autoimmune illnesses are...
  3. Snow Leopard

    Beware creating a moral panic about antivaxxers Fiona Fox The Times 2019

    This is correct. The fact is that vaccination rates in most countries is at or near highs and for MMR at least is high enough such that all cases can ultimately be contained before there is an uncontrolled/significant outbreak. Wakefield's ill-fated study had no noticeable effect on...
  4. Snow Leopard

    Circulating leptin levels in patients with [ME], [CFS] or fibromyalgia a systematic review protocol, 2020, Musker et al

    I've met Mike Musker and he's a decent bloke. I'd like to point out that he's the clinical lead, rather than a medical scientist. I don't really think the (Leptin) study is going to be a big breakthrough. But it is the first time so many samples have been taken within a short period of time so...
  5. Snow Leopard

    Shared Microglial Mechanisms Underpinning Depression and Fatigue and Their Comorbidities - (2019) Filho, Macedo,Freitas de Lucena,Maes

    Lack of specificity of scientific findings is not a strength, it is a weakness.
  6. Snow Leopard

    Rituximab and placebo response

    @Jonathan Edwards Speculation about this seems like a waste of time and is fundamentally second-guessing the purpose of a blinded control trial in the first place. Participating in trials leads to altered symptom reporting and some people by pure chance might be lucky enough to improve on...
  7. Snow Leopard

    Mystery illnesses reveal the power of our minds to influence health, New Scientist

    Neither. Biology is a process. You can't put human DNA in a test tube with all the essential nutrients for life and grow a baby.
  8. Snow Leopard

    The science of craniocervical instability and other spinal issues and their possible connection with ME/CFS - discussion thread

    First of all, we're talking about subsets of patients, secondly, physicians have long had selective vision and focused on the symptoms they want to see to validate their view of a particular disease. Patients play along by hitting the right notes (agreeing with the right words) so that they can...
  9. Snow Leopard

    Psychometric properties of the Cognitive and Behavioural Responses Questionnaire (CBRQ) in adolescents with CFS, 2019, Loades, Chalder et al

    Validated against what? They didn't ask patients whether they thought the questions made sense or whether they represented their illness experience. They didn't validate against any objective measures of functioning. Their "validity" is based on self-reference (similar bias applying to all the...
  10. Snow Leopard

    The science of craniocervical instability and other spinal issues and their possible connection with ME/CFS - discussion thread

    There is no scientifically demonstrated "placebo effect" besides transient pain reduction due to conditioning of the "endorphin" system. Everything else is regression to the mean (inevitable natural healing) or reporting biases. Undergoing very expensive, risky surgery very much is a major...
  11. Snow Leopard

    The science of craniocervical instability and other spinal issues and their possible connection with ME/CFS - discussion thread

    My worries are that lots of people with ME or CFS will worry they have CCI or worse, get misdiagnosed with it, get surgery and not have any sort of remission. Conversely, I also worry about the exclusionary aspect e.g. those people had a real disease, but the illness suffered by people with a...
  12. Snow Leopard

    Autonomic dysfunction in myalgic encephalomyelitis and chronic fatigue syndrome: comparing self-report and objective measures, 2019, Sunnquist et al

    The study also stated the (oversimplified and partially misleading, but common) assumption that: and I think it it's a waste of time trying to associate HRV measures with self-report measures since the biggest predictor of altered (reduced) HRV (compared to average population controls) is...
  13. Snow Leopard

    Do ME symptoms fit with the faulty energy metabolism hypothesis?

    The "fatiguing" test was conducted on the adductor pollicis (one of the thumb muscles), but this doesn't exactly put much strain on the cardiovascular system (though a blood pressure cuff was used during some of the tests). The result shows that the nerve function itself is probably normal and...
  14. Snow Leopard

    Australia’s Health Minister Greg Hunt announces $3m for medical research

    There was money promised for endometriosis research over a year ago and yet there is still no plan on how that is going to be spent. https://www.theguardian.com/commentisfree/2019/mar/28/greg-hunt-pledged-25m-for-endometriosis-research-were-yet-to-see-a-cent We cannot assume anything.
  15. Snow Leopard

    RCPCH conference 2019 abstract: When symptoms dictate a young person’s life..., Gamper et al.

    The abstract reads like a cherry-picked narrative. I don't trust this narrative either, unless the individual in question agreed it was true. The likely reality is there was a lot of medical malpractice and the patient is still severely ill. Terry Segall, one of the authors also wrote this in...
  16. Snow Leopard

    Do ME symptoms fit with the faulty energy metabolism hypothesis?

    I don't experience that pattern at all, makes me wonder if I have a different illness. For me, physical activity can increase brain fog, but prolonged cognitive activity doesn't make my legs any weaker.
  17. Snow Leopard

    Havana Syndrome: U.S. and Canadian diplomats targeted with possible weapon causing brain injury and neurological symptoms

    Here are some more Jon Stone doozies: "Trick or treat? Showing patients with functional (psychogenic) motor symptoms their physical signs." https://www.ncbi.nlm.nih.gov/pubmed/22764261 followup: https://n.neurology.org/content/80/9/869.1.long "From psychogenic movement disorder to functional...
  18. Snow Leopard

    Havana Syndrome: U.S. and Canadian diplomats targeted with possible weapon causing brain injury and neurological symptoms

    Reminds me of this speculative paper: https://spqr.eecs.umich.edu/papers/YanFuXu-Cuba-CSE-TR-001-18.pdf Claims it may be consequences of some sort of elaborate eavesdropping device. I'm not sure how credible that is though...
  19. Snow Leopard

    Havana Syndrome: U.S. and Canadian diplomats targeted with possible weapon causing brain injury and neurological symptoms

    This is their latest review (Jon Stone and friends) (I guess no one informed them about how inappropriate their analogy is): Structural alterations in functional neurological disorder and related conditions: a software and hardware problem)...
  20. Snow Leopard

    Where is this sophisticated research CDC's Suzanne Vernon said she was doing in 2005? what happened to the work and results?

    There were a few gene expression studies published by her from 2003-2009ish, I'm not sure what is being referred to apart from that. (she left the CDC in 2007) You can have a look here: https://www.researchgate.net/profile/Suzanne_Vernon/publications
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