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Wow, that shows substantial bias on the part of the authors right there. Glad Crawley called them out on that one.

Not that I know of. It seems strange that a hypothesis presented over 20 years ago has not only never been confirmed with reasonable evidence, but is assumed as a fact by some people.

I really don't know as there are no consistent HPA axis abnormalities in CFS studies so far.

This is a pilot study, it is designed to inform future studies, not demonstrate efficacy.

Here is my quick summary of all the data I have seen so far: van Ness 2008 Difference in Ventilatiory threshold Oxygen Consumption (VTO2) Reduction of workload at ventilatory threshold not reported Vermulen 2010 Reduction of workload at ventilatory threshold (difference between patients and...

They have all found issues at the ventilatory threshold at day 2 - it is the VO2peak that varies from study to study, I suspect it is because not all participants are reaching a true VO2Max.

I guess Dr Lloyd forgot to tell them about the study that he did that had a null result.

Resistance is futile?

The underlying cause(s) may be different, but there are common elements with other illnesses, though I agree most cases appear to be different from chronic viral illness. People with other neurological or autoimmune diseases who I have talked to personally often describe similar severe fatigue...

@Hole Ousia I apoligise for my speculation that you had prior beef with SW. I am curious as to which evidence you are referring to on long term harms of antidepressant usage. Specifically, evidence based on prospective studies. I know there is evidence of medium term reduction in 5-HT...

Simon Wessely's letter requesting a fresh review seemed reasonable. BMJ's news article not stating any of the reasons why the review was requested was odd and disappointing. Peter Gordon's request for transparency seemed reasonable. Simon Wessely's unwillingness to provide details was odd and...

Who do you think? https://www.scotsman.com/news/capital-clinic-gives-hope-to-me-sufferers-1-931697 Edit I should be more specific - Alan Carson and Michael Sharpe have coauthored manuscripts before. This clinic was involved in recruiting patients for the PACE trial.

All of the criticisms, presumably.

My test was done in a university clinic. It depends on the setup, some recent equipment may automatically ramp the power up in almost continuous steps. Some equipment require the power to be ramped up manually in steps, 10-15w is common. However the protocol/rate of increase for athletes can be...

One thing to note is that enteroviruses are fairly small and simple viruses, contrasted with herpes viruses like CMV and EBV that are large complex viruses with many genes, some of which are there to confuse the immune system. The fact that both can lead to the same illness is strange.

One key aspect to note is that the CPET protocol for healthy people can differ from that used in ME/CFS studies, specifically the rate at which the power is increased. This can lead to less time on the bike, but also less precision of the data. Solent Sports Science Lab (mentioned above) says...

That's disappointing, I appreciate the effort you went to though! I put in an application last week, but haven't yet had a response saying they're reviewing the applications yet. (only the automated reply) Best of luck to everyone here who applied!

I'm skeptical of the persistent infection hypothesis, at least for myself and a majority of patients. But I also can't discount,the handful of people who I know personally who are currently experiencing true remission - all of them used either antiherpes or combination antibiotic/probiotic...

Epidemiology in long term cohort studies - this way we can test the sensitivity/specificity of the different diagnostic criteria, estimate incidence, prevalence, duration, DALYs and even economic costs.

Hmm. Some forms of GBS are motor only, especially in children, so the asymmetry seems to be most significant difference. edit: there is discussion of asymmetrical GBS: https://www.ncbi.nlm.nih.gov/pubmed/17122947 edit 2: Ventral Horn involvement in GBS...