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If specific researchers insist on methods that are considered strongly flawed in other fields, then they should be discouraged from doing research. On the topic of respect, there researchers have not shown respect for patients - the deviation from the protocol is a deliberate attempt to...

Sure, but the key is that deconditioning does not explain the symptoms of most patients.

Most RNA should be found in the nucleus of the cells, not the serum. If it is found in any kind of pathogenic amounts in serum, something has gone very wrong.

The problem is that if you limit the exertion to 50-60% of max heart rate, you aren't going to build any fitness. This type of therapy is purely psychological. The same goes with the fad of high step counts - it is intensity, not step counts that builds fitness or strength. Higher activity...

I agree this would be an interesting question, along with measuring OI specific symptoms post exertion. Personally, I only experience OI after substantial exertion (for me), but it occurs sooner than the rest of the post exertional exacerbation.

Not yet published. Curious to see how many studies were included - given there are several other studies with similar results that are not yet published as far as I know.

The dispute was over opioid pain killers - the young woman was in a lot of pain, but the Mayo clinic, with all the controversy about the "opioid epidemic" took her off those pain killers and that is when the dispute started. Mayo is unwiling to be transparent about their actions - so clearly...

The HR of 5.31 shows a trend towards a risk for Guillain-Barré syndrome. Note that this is a relatively rare consequence (around 1/100,000 person-doses reported in other studies of vaccines) and this study simply does not have the statistical power to detect events of that frequency with...

It looks like Jake is going to speak out in support of the participants, which is certainly an interesting twist.

Wow, that's awful! There is something really messed up in our culture when medical practitioners use such dirty tactics in retaliation.

The difference (in this case) is that prominent people involved with the Cochrane collaboration were the ones making the criticism.

Quite right. A lack of specificity of an association means it is likely not to be causitive. I mean you can't blame total resting, continuing to do the same amount, and everything in between as a specific prognostic factor.

Actual article is here (in Spanish): https://www.actaspsiquiatria.es/repositorio/20/114/ESP/20-114-ESP-125-32-297763.pdf The descriptive statistics are shown in table 3. They used the 1994 CDC criteria. The highest (mean) score for those with "personality disorders" was 1.69 which lies...

The alterations observed in the study are trivial and easily reversed as the person resumes their regular routine. I'd love to be able to exercise regularly (cycling, orienteering etc), but despite trying my own modest exercise program over several years, I haven't been able to increase my...

Reminds me of Andrew Lloyd frequently claiming CBT works when speaking to the media. (conveniently forgetting that his study found no effect compared to a medical placebo).

Who the fuck calls a trial "Fatigo" anyway? Clearly they don't like patients much.

The only meaningful cytokine association regularly reported in the literature is TGF-Beta, and well, they didn't test for that in this study. White even did a systematic review highlighting TGF-Beta so its absence is notable.

Claiming there could be a ceiling effect and not providing a histogram/visualisation or statistical test of the effect, leads to the claim lacking credibility. You'd lose marks doing this on an undergraduate project, it's simply not acceptable from professionals.

The trap of circular reasoning...

Thanks for sharing your experiences. The blood tests will hopefully be interesting. There is no stopping and starting, I'm not sure where you got that idea. The only difference between tests (in different venues) is the power level of warmup, the length of the warmup and the rate at which the...