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Open label, sigh...

Notice also what all of these have in common (along with convulsive vasovagal syncope)? They are all acute phenomena that have short timeframes, they are not equilibrium processes, they are not self-sustaining.

The problem is they don't use such (eg measurements of cortisol or catecholamines) in a systematic manner. You can't just measure cortisol once, along with a questionnaire and jump to some sort of generalised conclusion. There is a lot more involved, especially if you are trying to invoke...

The publisher has existed in the Netherlands since 1987 and this particular journal since 1990 https://content.iospress.com/journals/work/1/1 The problem is that if many universities don't have access to the article (this is a paywalled journal), then no one will ever read the paper.

I don't see publishing fee at all, this is not a fee-to-publish open access journal. They are not on any of the lists of predatory publishers either. https://en.wikipedia.org/wiki/IOS_Press https://predatoryjournals.com/ However, that doesn't mean that there aren't more suitable/higher quality...

This looks to be a good quality study at first glance, there didn't seem to be any compelling group-wise differences between patients and controls. Looks like another unnecessary test, hopefully this will save some patients some money...

There is no evidence for the app itself, which has not been tested in any clinical trials. The reference list are a few narrative reviews on "mind-body therapies" and the "biopsychosocial approach", along a few clinical trials with quite varied "mind-body" therapy approaches for conditions like...

Positive predictive values were poor, mean years - sensitivity - PPV (manually calculated by me for all you Bayes lovers) 9.7 - 11.5% - 6.3% 10.6 - 13.3% - 3.5% 11.7 - 9.84% - 5.0% 12.8 - 18.6% - 4.1% 13.2 - 16.7% - 6.8% 13.8 - 35.2% - 4.4% (curious loss of specificity, with a gain of...

More recently than May 2016, which is the only version on the Wayback Machine and did not have any references to such research. The notable part is they only care about difficulties answering the questions, not whether patients believe the questionnaire is relevant to their illness.

The problem is that there is a common bias, namely questionnaire answering behaviour. This method does not separate the effect of (a negative bias on) questionnaire answering behaviour from depression itself. The only way to resolve this is to use objective measures of fatigue on functioning.

The difficult part is establishing the relationship between cause and effect. Certain underlying risk factors may predispose for the outcomes above as well as doctors prescribing behaviour...

That is a bold claim... Sigh. It is not the lack of literal meaning that is the problem, it is the lack of meaningful application. There is no parallel to executing software on a body.

Brains are not arrays of digital logic gates with a fixed network configuration. Nerves themselves can die or regenerate, it is not merely the 'switching' (nerve firing) that is important. Epilepsy causes structural changes, so I'm not sure the analogy holds there. (note: a seizure is a...

Unless they provide a histogram, and account for participation biases... There may still be a lack of sample size to make any conclusions about an earlier age peak too.

Copied post Unless they provide a histogram, and account for participation biases... There may still be a lack of sample size to make any conclusions about an earlier age peak too.

I can't help but chuckle at the word "stressology". The problem with stress is the more people who use the word in ever increasing range of contexts, the less specific the meaning seems to be and the less useful the word is as a result. Despite the fact that he has tried to test this...

I need to clarify that the age doesn't really tell us much. The average age at enrolment in the study was 44.9, and the study only went for 2.4 years so this study can't really capture what happens at other ages.

I made a mistake, the lifetime prevalence didn't report sex, 57% was the overall sample. However 56% of the new cases were women.

It's not working for us at all. Are you able to download the full PDF?

Because people sat down and wrote "software", which ultimately a list of binary logic instructions telling a digital computer what to do in a linear manner. Formal languages (including programming languages) are very different from our thoughts, or biological signalling networks. Life is a...