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This is true, but it's also irrelevant when they can't objectively demonstrate efficacy for people with non-specific CF, let alone CFS or ME.

Looking forward to Gategategategate being published!

The large unexplained variance is due to the unreliability of the questionnaire itself. This is not specific to the questionniare used (it may be one of the better ones), but an inherent flaw of questionnaires in general.

How about a third investigative reporter reporting on the second? We can call it Gategategate.

I found this curious. The risk of autoimmune diseases in first degree relatives is discussed here: https://genetics.emory.edu/documents/resources/Emory_Human_Genetics_Autoimmune_Disorders.pdf Two out of my three siblings have autoimmune diseases (Type 1 Diabetes, autoimmune Thrombocytopenic...

I agree, it is a perversion of the term. A Randomised control trial requires a (patient) blinded control arm.

I don't have time to post the studies (I have posted them all in one post previously), but no RCT has found SSRIs effective for ME patients for any symptom, including depression. So SSRIs are not evidence based treatments. There is some evidence for tricyclics to be effective for sleep and...

Yes, the lack of communication is quite disappointing.

The primary function of Glucocorticoid receptors is metabolic. Hence the name Gluco... Sounds like Hell to me...

Exactly. They frequently talk about doctor shortages, but there has long been a surplus of medical school graduates. The only "shortage" is the money for training doctors.

We do get hit within a short period of time after the activity, it is just the worst seems to come 24-48 hours after exercise. The muscles used directly in the activity are hit much harder than any "PEM" that affects the rest of the body.

I don't paint! I knew I was doing something wrong. :laugh::laugh:

There have been some further questions and answers by one of the authors that some may find interesting. The conclusion is that while haematological factors are central to VO2Max, blood volume might not always be the rate limiting factor. One of the authors suggested that peripheral factors...

It's still basically a questionnaire item.

In many patients it is within the same range as controls and even when it is not, cortisol secretion patterns during the day is directly related to day to day metabolic demands and sleeping rhythms, which can often be quite different in a person who is not working full time versus someone who is.

yes, they need to correct the mistake. It's worth writing a comment that the abstract is wrong on Pubpeer at the very least.

The problem is they didn't measure fatigue. They recorded responses on a questionnaire (which was never tested for quality, in terms of relevance/understandability etc), at two time intervals and the questions themselves were retrospective and potentially subject to a variety of biases. So any...

You are aware of the problems yet you use poor quality instruments anyway? A poor foundation means poor results. Just because developing an instrument properly can be time consuming doesn't mean it should be avoided. You said you are not attempting to generalise, but that is the primary...

Funny how they conclude that increased cytokines and cortisol is a good result. Such findings may simply be due to different activity patterns before and after. I really don't know why you'd design a study like this, but... meh

The abstract is interesting, but well, highly speculative. Direct link here: http://mjms.mums.ac.ir/article_10458.html Article is in Persian.