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The paper discusses the rational for a short 3-4 hour training session and some of the communicated responses, however doesn't really discuss in much detail about the specific content of the training such that someone else could replicate it...

That's the Nobel prize winning question, but the authors specifically mention this paper: https://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-8-93 Which along with the other 2 day cpet papers and related findings in exercise physiology provide clues, at least in my...

Another finding that didn't replicate...

Oh sorry, my mistake.

The notable part about all this is well, short walks don't lead to improved fitness. Either short intense activity (to build VO2max), or prolonged exercise just below the ventilatory threshold (to increase endurance) is required for improved fitness. If you are reporting substantial benefits in...

The parental associations are likely due to participation biases, namely demanding parents are more likely to have children participating in such studies because they want answers. The noteworthy part is the bias applies to the parents, compared to biases of patient participation and response as...

The problem extends to the followup, namely loss to followup and related biases in the case of the GP who enrolled the patient into the study was not helpful, or worse...

Sharing widely is not likely to get an article retracted and is likely to be counter-productive. Sharing with prominent people in authority who may be able to leverage a correction on the other hand can be helpful...

This study could be quite valuable if done correctly, but won't be because the people running the study don't bother to listen to patients when it comes to study design...

I think you missed my point. Yes they have a policy. I'm saying that policy does not meet patient needs in all cases. I'm saying we shouldn't be trapped in bureaucratic hell because they didn't bother to ask us before making a policy. We don't have a name like SEID [Ramsay], we have an even...

Mhmm ;)

Yet another narrative review recommending SSRIs, this one notably does not mention any references. The reason for the lack of references is because all double blinded studies of SSRIs for CFS patients failed to show any benefit for any symptoms including depressive or anxiety symptoms. I don't...

Wouldn't that be an open skull? I thought the problem with open minds is they have a tendency to fill up with trash.

I think my previous response was badly worded, I mean we don't have serious winter here, like you have in many parts of the USA. (I hear there were even snow storms in California!) I live in South Australia, it never snows where I live.

Since Jonathan didn't have a go, I will try. Phantom limb phenomena relates to the fact that the mind (as a result of development of a young organism) builds up a model of the limb and this is used as a comparative basis for proprioception (including effort perception) in general. This is one...

The argument against naming diseases after people is based on stigma, whether the name leads to confusion about etiology etc. Those arguments don't necessarily apply to the argument that ME should be renamed as Ramsay disease. Secondly, if the names proposed by various health authorities...

This doesn't prove that the conditions are similar, it proves that the questionnaire lacks specificity. Which is something that patients frequently mention when filling out such questionnaires (and often ignored by researchers).

Not really, no. But we don't have serious winter here like in the USA.

Brenu et al note no difference in deformability using a different methodology. Saha et al note that some patients were taking various medications such as LDN, Rituxan, Vitamin D etc and this could well affect the results, especially given the small sample size. Secondly, no sensitivity of...

Both the Mirtazapine + CCBT and CCBT + Mirtazapine groups, as well as the Placebo + CCBT and CCBT + Placebo should have similar results at 24 weeks unless the study suffers from short term biases. The reductions in the Fatigue Scale (Chalder) score at 12 weeks were small and not of clinical...