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Is this the problem though? Dilation of arteries leads to reduced blood pressure and heart rate due to increased blood flow. Note that the post exercise hypotension noted in healthy people is likely associated with prolonged dilation of arteries (1-2 days) and proportionally more blood being...

The problem isn't frequentist hypothesis testing, the problem is people inappropriately assuming that because a finding reached a pre-defined alpha, that it is automatically true.

I have great confidence in your conclusion. ;)

If they truly have chonotropic incompetence, there is no "forcing", the patients will simply need to stop early. What is interesting is that in young healthy people, deconditioning can actually result in slightly higher than normal heart rates at VO2Max than trained participants. The idea is...

Yes. They have dropped the ball for a long time. ME is a special case and it is in their scope to focus on building research capacity, which means funding more specialist centres (which will lead to more pilot studies and in turn more NIH applications). Most scientists don't want to build a...

The purpose of this study is to discover/further characterise rare genetic diseases...

It's not for her benefit, it's for his benefit, so that the uninitiated readers of his tweets will assume she's just misinformed...

Sure, but elevated heart rate can have a variety of causes and does not necessarily indicate that anerobic respiration is becoming predominant, which is dependent on muscular drive. Heart rate in general depends on cardiac drive (and balance between parasympathetic and sympathetic drive) and is...

How do you know? Have you measured your ventilation or intravenous lactate while doing such activities? High pulse (in cases of POTS for example) is not the same as exceeding a ventilatory or anerobic threshold. Impact post the initial followup was through regular phone calls, with patients...

Yes, the whole point of sitting on the bike was to see if there were any major problems. Severe patients do not participate in studies like this. The act of moving onto the bike might be vaguely aerobic, but the sitting is not, even if you have POTS.

It is not true that sitting on a bike is "an aerobic activity". The fact that there was no difference between patients and controls on the first day suggests any modest pre-test activity was insignificant.

That's true, but shitty people writing shitty things in the media is much of the problem... Re-read all the shit Rod has been writing about ME over the years and you might change your mind...

Do I really want to read this? :nailbiting:

Yes, seems strange. If they were referring to VO2Peak it would make much more sense. But I suspect the statement is a response to reviewer concerns who felt that the differences in reduction in WR at VT needed an explanation... I participated in this study and I'm telling you that besides any...

APT is not a "matched" control because it does not control for differences in biases. In APT the patients were basically trained to be very aware of their symptoms, whereas in CBT/GET, the patients were trained not to be as aware of their symptoms, and more optimistic in general. It's clear how...

What about those of us who did initially have neurological deficits suggestive of neuropathy? (in my case, acute flaccid myelitis with a Polio-like gait)

The problem is this mental vs physical narrative is not driven by patients, but primarily driven by people who naively or deliberately mischaracterise patient views... Patients have always been on the back foot, on the defense since the 80s, with the yuppie flu etc nonsense.

News outlets run factually incorrect articles all the time, regardless of what the people interviewed in the article think. (especially the latter publication)

It is notable that when people ask intelligent questions, particularly relating to ambiguities in his reasoning or evidence, he simply does not reply. But he does occasionally reply to the accusatory comments... Exactly, and it's quite reasonable to expect that similar things have been sent...

Look, while the danger is mostly just people writing nasty emails and tweets, we shouldn't keep demanding evidence of how bad the danger is. We should be telling people that such things aren't really helping anyone (as Esther12 is saying) and pointing out it is a small minority of people...