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One of the comments: The guy recovered eventually though... Though maybe it was the physical activity that exacerbated the symptoms post-EBV in the first place...

Case-control study... I guess this was overlooked as part of their previous population based studies.

Funny coincidence, I remember a quack (homeopath) saying more or less the same thing - and I agreed. (I was 17 at the time) Of course I was doing almost nothing at the time and still had brain fog, constant headache etc. ¯\_(ツ)_/¯

From that link: A more recent prospective study in Germany found an (CC) allele frequency of 24%. So in both studies, the (reported) ethnicity is neither a highly sensitive nor highly specific predictor of having the gene and hence treatment results. The conclusion is clear: we should not...

When it comes to (medical) cures for disease, I have not seen any evidence to suggest that "race" or ethnicity have any effect, beyond access (and compliance) to high quality medical care in the first place.

Which based on the reported concentration of 200 cells per microlitre means 10,000 cells...

That was a mistake in my part, I was meant to say microfluidic channel. The flow is just during filling... I agree, a clearer diagram of the geometry would be much more helpful. The manuscript I linked however stated: The other manuscript stated: Note the latter (bolded). I wish the width...

Yes, it is a little disappointing that they didn't provide impedance vs frequency curves and the only impedance graph over time they provided were of the purely resistive component (Zre). The magnitude of change was much greater for the resistive component (Zre) than the reactive component...

I don't know what Simon means by "micro chamber", but the schematics show multiple nanoneedle sensor tips perpendicular to the microfludic flow. Like most binding processes, cells forming an interface near the coating on the electrode is a dynamic process and the measured impedance reflects the...

On that topic, I wanted to do a research thesis involving microfluidics, back in 2015/2016 and the overlap between Dr Davis' ME research and microfluidics was intriguing to me, including that paper. I majored in Chemistry, but microfluidics was really the only area I was really interested in...

Most ME/CFS patients have a disease but this is not the same as CFS being a disease...

Is there any evidence for this in human cell culture or PBMCs? The studies showing differences are in animals where there are sex specific differences at the organ level (as a result of different hormone/endocrine signals), but not necessarily the cellular level. It is still disappointing that...

That was around 15-20 years ago, the real issue is no one has bothered to check whether such lack of diagnosis occurs recently. The same goes for many non-western countries (and countries outside the sphere of influence of Japan). I'd like to see high quality epidemiological studies in India and...

Glaring errors are the norm for mainstream media... It is just that we don't notice most of the time... See:

Indeed. It is inappropriate to derive conclusions from pilot studies like this.

The problem is "stress" is very nonspecific and tells us almost nothing about disease initiation or progression. Similarly, psychological "stress" is neither necessary, nor sufficient to trigger ME or CFS. Hence while "stress" may be a risk factor, it cannot be blamed as a cause.

As far as I know, there is no EBV vaccine so this remains hypothetical...

It's frustrating that they didn't focus on reporting the absolute activity levels (based on actigraphy) before and after. It would be more interesting to see what variables predict activity at followup, rather than self-report physical functioning or fatigue which is a more indirect measure.

Perhaps they should do the reverse study - patient informed education for practitioners treating patients with MFSS...

It seems you all have a very short memory...