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There's some discussion about matters related to Forward-ME here (follow the arrow in the quote header)

An interesting paper from this New Jersey team. They suggest that the problems of less efficient brain function, essentially the brain throwing a whole lot of de-synchronised effort into producing motor outcomes that are similar or worse than normal, that they found during the acute Covid-19...

That youtube video by Eiko Fried linked in the tweet above is great, well worth a listen. I'll put another link here in case something happens to the tweet: In the last section, he comments that the same criticisms have been made about research into other sorts of therapies and mentions CBT...

Thanks SNT, a glossary certainly helps with this one.

I think it's important to call a spade a spade. If we call it a functional digging implement, people will be confused, and think it might be a term that they can accept and even be proud of. 'Functional disorder' and even 'conversion disorder' leave room for a lot of ambiguity for the patient...

:cry: So very sad. Thanks David for posting these testimonies. Edit I've just read Naomi's blog and it is extremely good, well worth reading

I wonder if McEvedy and Beard would have been interested in the Royal Free outbreak if there had not been a number of cases of persisting illness following the acute illness i.e. what seems to be straightforward ME/CFS? Was their dissection of the outbreak a means to suggest that the persisting...

Thanks Kiristar. There's a paywall to make comments on the article, but if anyone wants to use any or all of my post to build their own comment, please do so. Comments signal to the paper that there is an interest in the topic.

I think this was an interesting paper, making good use of retrospective data. It seemed to me to be well done, with good recognition of the limitations. Thanks to the authors for their ongoing interest in ME/CFS.

Ideas arising from a recent van Campen study: undertake analysis of cerebral brain flow (CBF) and cardiac output (CO) upon orthostatic challenge in all ME/CFS patients, not just those reporting orthostatic symptoms and not just those with a normal HR and BP response to tilt testing. compare CBF...

Limitations/ future research ideas: Yes, good ideas: undertake the analysis in all ME/CFS patients, not just those reporting orthostatic symptoms and not just those with a normal HR and BP response to tilt testing. compare CBF and CO measurements on good and bad days investigations into the...

On possible mechanisms Of course, this study only looked at people with a normal response to the tilt test in terms of heart rate and blood pressure. Blood pressure may be changing with posture in some people at least some of the time in order to try to maintain cerebral blood flow. I've seen...

These paragraphs from the discussion are worth reading: It would be worth looking at these papers that have evaluated the use of compression garments. I'm not sure how you could blind such studies, and so any reported benefit would either need to be both sustained and substantial or...

The flow was the sum from the carotid and vertebral arteries. Stroke volume was the velocity of blood passing through the aorta in one heart beat multiplied by the (corrected) aortic valve area. So, the speed of the liquid and the size of the pipe. Cardiac output (CO) was the stroke volume...

This is just in the patient group with the abnormal %CBF change. The first sentence in that paragraph is a bit confusing - the %CBF reduction was not found to be correlated with all those factors. When they say 'related' they mean that they examined the relationship between %CBF and each of the...

I agree that us mentioning McEvedy and Beard in articles like this might well strengthen people's association between ME/CFS and psychosomatic illness. But this article was mostly good, and I appreciate that the health correspondent took the time to write about the issue. Jim White seems to...

1135 ME/CFS patients attended the clinic in ten years (met Fukuda and Carruthers(is that CCC) criteria) and who had a tilt test due to suspicion of orthostatic intolerance. 664 patients had a normal HR and BP response. Patients younger than 18 years or with a very high BMI were excluded...

Very small control group The study found a decent correlation between fibromyalgia severity and mitochondrial function. However, it didn't find a correlation between the symptoms severity scale and mitochondrial function. The SSS measures a mixed bag of symptoms, and so the lack of a...

The first figure B above does seem to suggest that most of the fibromyalgia samples are lower than the healthy control samples though. There are some possible reasons why faulty mitochondria could be the problem even though some of the fibromyalgia samples look the same as the control...

I expect so, I was trying to indicate the catchment region of the service but I am lacking in UK geography knowledge. I'll change it.