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Ah, the famous In-fernal Cycle, with all those perpetuating spores...

You might think that perhaps the authors live in some part of the world that is under-resourced, where a "multi-component long COVID treatment program based on central sensitization" hasn't been tried before and where they have not had the benefit of exposure to informed ME/CFS and Long Covid...

Well, there's this paper that the forum initially missed: Post-Covid-19 Conditions in Children, 2023 by Hahn et al. with its message of 'Long Covid; nothing important to see here, move along' Fortunately, there was a retraction notice later on, so that we caught up with it. :) RETRACTED...

It really is. And count the, well, what do we call them? Lies? Evidence of deluded thinking? Misrepresentations? 1. "Innovative" - nope, just the same old stuff 2. "Central Sensitization is a primary mechanism for the development of Long COVID symptoms." - no, there is no evidence that allows...

And we've asked them in multiple ways - letters, formal complaints, communication via back channels, face to face conversations, and to the Board generally and individual members, to the Chief Editor, to Hilda, to specific Cochrane office holders including people we know personally. All we get...

On the sIL-2R finding: They tested a lot of things (65), IL-2R on the left does look interesting. They investigated the impact of SIL2R and IL-2 (separately) on the oxygen consumption rate of a type of muscle cell in the Seahorse machine. Figure 4 certainly is interesting. That's a big...

On the results: Activity At this early stage of the illness, muscle size, fibre composition, and muscle strength were still similar to the healthy controls. Three participants (27%) reported no change in activity after infection, of which two had been highly active, and one was intermediately...

On the methods: People were eligible to participate as soon as 4 weeks after the Covid-19 infection, and they just had to report ongoing fatigue. The average time after the positive test for the acute illness was only 59 days. And the healthy controls were mostly historic pre-pandemic samples...

Thanks MIJ and SNT This is a paper from mostly a University of Kentucky team, with varied backgrounds but a substantial focus on muscle biology. NIH funding They appear to have started with the idea that there is something in the blood of people with PASC that causes mitochondrial dysfunction...

Which again goes to the problem of 'is that exercise test enough to cause PEM or general deterioration, which would be the reasons why activity would reduce?'. The people with (ME)/CFS who volunteer for these studies are not put off by the prospect of 8 minutes or so of cycling, because they...

That's a manipulative survey. Shame on them, when they know that the patient group they serve has been harmed by manipulative surveys.

Article on the research In particular, I note this "The research team has a study underway that could shed light on the persistence of these symptoms in individuals experiencing long COVID, including the long-term impacts on neurocognitive behavior and memory loss."

Link - open access In mice Venkatramana D. Krishna1, Allison Chang2, Holly Korthas3, Susanna R. Var4, Davis M. Seelig5, Walter C. Low2,4*, Ling Li2,3* and Maxim C. -J. Cheeran1* Minnesota team Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent of COVID-19, is...

Post moved to USA - Mayo clinic - review of a doctor there

We have a new petition update today: Thanks to our supporters Thank you to the 11,300 people supporting the campaign from 76 countries. Thank you also to The Grace Charity for M.E. for adding their support to this campaign. We now have 76 organisations calling for the 2019 review to be...

I know that people can and do learn new things, and I don't expect people's expertise to only be defined by a qualification they gained years ago. But, I think Gladwell's PhD topic and subsequent promotion of TENS says a lot about the way he thinks. The evidence for the effectiveness of TENS is...

I see from @Sly Saint's post on another thread here, that AfME has acknowledged S4ME discussion in a revision of another document. But that document still has problems, so it's almost worse, to be listened to and yet our points mostly ignored. We've been heard, our name is now on the document...

Is there any way we can get someone in AfME to read this thread and respond? You would think that an organisation dedicated to advocating for ME/CFS would see the forum as a useful window onto how their initiatives land with people with ME/CFS and would be monitoring it. Failing a proactive...

Welcome to the forum @jnmaciuch. Looks like you are going to fit right in. I hadn't seen this before, taken directly from the PACE Participant Manual: You write very well. I think a paper examining the harms of the CBM beyond physical harm would be useful. Just some of the interesting points: