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From the discussion: Ref #53 is Plasma Markers of Neurologic Injury and Inflammation in People With ... Neurologic Post acute Sequelae of SARS-CoV-2 Infection, 2022, Peluso et al That study only found elevated GFAP early in the disease of those with Long Covid, and not later. I get the...

I note the affiliation of the senior author: Matthew Campbell View ORCID ID profile Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland FutureNeuro, Science Foundation Ireland Research Centre for Chronic and Rare Neurological Diseases, Royal College of Surgeons in Ireland...

I've just looked at reference 65 - thread here Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment, 2024, Greene et al Although the cohorts were small (e.g. 11), the results from the MRI with contrast did look pretty...

Coming back to this, given that Nath recently said that he was confident that there is no blood brain barrier dysfunction in Long Covid. The findings on blood-brain barrier dysfunction based on the MRI scanning with contrast still look pretty good.

The abstract of the preprint is in 2023 is in the first post and the published abstract is at this post. It looks as though the paper received quite a bit more polishing. Also, there's substantially more on gene expression.

Montpellier, France It wasn't that difficult to believe the disease could be chronic. But at least this team understands that there is no treatment. (Perhaps 'basic' is a translation error? perhaps meaning 'disease-modifying'?) I'm aware that Jonathan doesn't think much of the idea of NETs...

If childhood abuse did cause Long Covid, it would be great if governments suddenly decided that there was an economic reason to stop childhood abuse and set about reducing it. But I suspect the response to any such association would not be to fix society. Perhaps some of the people who do these...

From the abstract, I think the argument is a bit more nuanced than 'you can only study things that are acceptable to the target population'. The wording is 'properly take account of'. There is also the 'even if it requires other experts to determine how those reasons are best to be respected in...

It doesn't sound terrible, but the outcome looks to be a subjective one: So, we have the common problem of a subjective outcome in an unblinded study, and confounded by some likely disease-unrelated improvements in wellbeing resulting from weight loss in those participants fortunate enough to...

Results of a brain scanning study from a Canadian team is out: A Multimodal Magnetic Resonance Imaging Study on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Feasibility and Clinical Correlation, 2024, Kaur Mentions a patient registry.

Yes, that paper: was the one I was looking at too. And they did find a relationship between the cerebral NAA and cognitive abilities, as the title suggests. With respect to actual measured IQ, the abstract goes on to say: I haven't looked further into the paper, but it sounds as though they...

So, magnetic resonance spectroscopy only in three regions of interest: anterior cingulate gyrus (ACC), left dorsolateral prefrontal cortex (L-DLPFC) and the brain stem (BS). Patient selection looks to have been fine - i.e. from a registry, diagnosis confirmed by physician interview, PEM...

Transcript of the spoken message on the tweet: Much respect for the effort the people involved in the Chronic Collaboration have put in over the years. However, I do hope that they will think carefully about their documentary. Just because it is a doctor who has said something, that doesn't...

A thread relevant to Gladwell: Open letter to Action for ME with concerns about their promotion of a problematic Care and Support Plan Template regarding his authorship of AfME documents and involvement in UK ME/CFS charities.

It is very hard to understand what led to this document being published. Sonya's been around the block a few times now, her understanding of ME/CFS seems to have grown over the years and she is reliably coming across well in interviews. So, was she just not aware of the detail of the document...

Great letter @Trish. It's bloody annoying when we have to use energy trying to fix mistakes that patient charities make. There are more than enough things to do in advocacy without our charities actively contributing to the misinformation and stigma. I really hope Action for ME listens and...

I don't understand the abstract. It was sounding like a useful system for assessing fatigue from various sensors. Something like that could be useful for a study in ME/CFS, e.g. to quantify what happens after an extended period of walking when it seems like it takes a lot more conscious effort...

From eAppendix 3: This paper gives us detailed Tables 1 and 2 (telling us how many tests were the same or different at the first and the follow up visits. But, that's almost meaningless. What we really need is the actual data. For instance I want to see the actual copeptin data...

Copeptin? the following is mostly from Wikipedia I've gone on about how I routinely get a high shock index and how, for me, a higher shock index correlates with symptom load. I don't know why it isn't measured and reported in ME/CFS and Long Covid.

I approached this paper with trepidation, wondering what fresh hell Walitt was visiting upon us. Perhaps he didn't get the right to decide the wording this time. The study only had 7 participants, and so far it doesn't look as though they found one thing that might explain the long Covid...