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I think this study doesn't provide proof for the assertion of the title. We can't tell to what extent persistent neurological manifestations are prevented by vaccination by looking at the people who make it to this clinic, apart from being able to say 'vaccination does not completely prevent...

Capsaicin may have important potential for promoting vascular and metabolic health "Capsaicin, the phytochemical responsible for the spiciness of peppers, has the potential to modulate metabolism via activation of transient receptor potential vanilloid 1 (TRPV1) receptors, which are found not...

Our thread on the RestoreME oxaloacetate trial: RESTORE ME: A RCT of Oxaloacetate for Improving Fatigue in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), 2024, Cash et al Our thread on the Valacyclovir+celecoxib trial protocol: Valacyclovir Plus Celecoxib for Post-Acute Sequelae...

One on oxaloacetate, one on valacyclovir and celecoxib. I think we have criticised both of these trials. I have a fair bit of time for the Bateman Horne Center, but I think a number of the trials that are done there are problematic. It's such a shame, as the Center could be contributing a lot...

Where are the comments @JohnTheJack?

Professor Jonas Kunst has some good comments on LP:

Cortisol levels are radically different depending on what time of day you test (specifically, how long after your usual wake up time and your latest wake up time). And other things seem to affect it such as pain and other stressful events. Cortisol levels also change to match the level of...

So, actually only three had 8 am cortisol levels below the cut-off level. Also, I don't believe an 8 am cortisol level less than 138 mol/l necessarily means that the person is hypocortisolic. As we have discussed elsewhere, cortisol levels vary a lot over a day, and someone who is not working...

238 people infected with SARS, 33 died. 205 people survived, 2 with pre-existing hypothyroidism excluded Of the 203, 60 met inclusion criteria and agreed to participate, enrolled at 3 months post-discharge So, quite a lot of people did not participate. I suspect that the authors would have...

I'm not sure if the authors understood 'psychosomatic' in the same way that I do. If an endocrinological basis resulting from a disease process accounts for psychosomatic manifestations, are they really psychosomatic manifestations? It all gets quite circular, but I think one bit of semi-solid...

Long covid studies Distinguishing features of Long COVID identified through immune profiling, 2022, Klein, Iwasaki et al This Iwasaki paper has been very influential in promoting the idea of low cortisol in people with Long Covid. A large study Noting @cassava's excellent post on the Iwasaki...

We have a forum thread on that study of isoforms of IFNAR2: Regulation of human interferon signaling by transposon exonization, 2024, Pasquesi et al.

That's a lot of dropouts. e.g 24 participants in the endurance group, of which 10 dropped out for various reasons 20 controls, 6 dropped out

Hydrocortisone studies Low-dose hydrocortisone in chronic fatigue syndrome: a randomised crossover trial, 1999, Cleare, Wessely et al 32 participants. The participants' urinary free cortisol levels were normal throughout, although did increase with hydrocortisone. Low-Dose Hydrocortisone for...

An Etiological Model for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2011, Jason et al This paper isn't a study, but I just wanted to flag it to show that even people that we might think understand ME/CFS quite well can have some whacky ideas built on this false idea that cortisol is...

Bobbler, sorry. The posting today is about old papers and the point is indeed to critique them, specifically about the idea that there is a solid body of evidence suggesting people with ME/CFS have abnormally low cortisol levels.

With an attitude like that SNT, you would never have been selected for the study. Clearly you have an unwillingness to change ;) (and way too high a risk of making it clear in the assessment that, no, even though the therapist was nice, and tea and biscuits were pleasant, you are not in the...

Characterization of Cortisol Dysregulation in Fibromyalgia and Chronic Fatigue Syndromes: A State-Space Approach, 2020, Pednekar et al This one is a thoroughly awful paper, it's hard to say what they found. There does not look to be any differences in cortisol between CFS and healthy control...

Coming back to this: This study measured cortisol levels in blood before and after the 2 months of seated yoga. Cortisol (μg/dL) reference range 3–20 Before 11.5 ± 8.3 After 10.4 ± 6.3 P value 0.552 So, the participants had very normal cortisol before and after the intervention. There was no...

Japanese study of yoga The longitudinal effects of seated isometric yoga on blood biomarkers, autonomic functions, & psychological parameters of [PwCFS], 2019, Oka et al This study measured cortisol levels in blood before and after 2 months of seated yoga (classes and practiced at home, for an...