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But since people experience PEM at different times after exertion, you would probably have people at different stages of PEM if you had blood collections at specific time points.

I was recommended any of these three by a researcher at my university (he works with translational neuroscience): Eric R. Kandel – Principles of neural science Dale Purves – Neuroscience Larry Swanson – Brain architecture: understanding the basic plan He said Purves was the most accessible one...

I haven't read the whole thread @Wonko, but I definitely plan to. I'm working the same angle, mostly with foods (high nitrate foods, antioxidants, vitamin E, omega3, electrolytes). I'm also testing red light therapy at the moment. I see you're testing out ketosis, I've never had any luck doing...

I don't see how the pro BPS people have a "broader perspective", they do repeat themselves again and again, they don't seem to value input from either patiens or biomedical research. That, to me, seems more like a closed mindset. And wording it like it's "pure biomed" vs "broader perspectives"...

That depends what the body uses it for ;) It can regulate different things in the body. In this case it mentions how it can induce a pro-inflammatory state, which would be useful depending if you need the immune system acting up. It's a vasodilator, so it can increase bloodflow to tissues...

Interesting. There was one exertion study on CFS-patients where they measured high levels of NO metabolites, although I can't remember seeing this repeated in other studies. From: https://www.liebertpub.com/doi/10.1089/jwh.2008.1255#B7 Couldn't find it at scihub unfortunately. Also I have no...