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Yes, I've noticed there are some member tags that do not auto-complete or come up in a search, yet seem to still be valid members nonetheless. AfME are @Action for M.E., though I don't think they have interacted here for quite some while.

Does this also touch on the issue of Control, within and across trials? Presumably you could have several trials, each of them a properly designed properly controlled trial, all notionally trialling the same intervention, with notionally the same patient classification. Within the context of...

Yes!

https://www.sciencemediacentre.org/wp-content/uploads/2019/10/Advice-for-Researchers-Experiencing-Harrasment-2019.pdf

What evidence is there that it is normal? Given how subjective it is, how can we know how the scores correlate with actual fatigue?

Yes, I see what you mean. The divergence of the PACE data from a normal distribution will be significantly influenced by the non-linearity of the data. But the non-linearity of the data is hard to pin, because the data characteristic is pretty unknowable anyway, especially the Chalder FS. Is a...

Yes. I cannot claim to follow all this by any means. But any analysis inevitably has to make certain assumptions about the data being analysed, because the tools being used are themselves based on various assumptions about the data. So a valid analysis should itself include justifications of...

The leaflet has one overriding omission: Are those objecting to your research right? Are their objections scientifically sound. They seem to gloss over this rather important point. Providing strategies for researchers to counter these upstarts. This one for example, which is clearly a #1...

Yes. How are you now, compared to before you got ME? "I feel terrible." ... some weeks later ... How are you now, compared to when you last filled in this questionnaire? "About the same." Wow! Fantastic! So glad to have been able to help you!

Yes @JaimeS. This is what my (somewhat rambling) post here was getting at. As we know, PACE a la GET was in no way seeking to trial a hypothesis of deconditioning; it was done on the assumption that the deconditioning theory for pwME was already established fact, already proven. They...

Indirectness of evidence. Yes, this makes excellent sense to me. Investigators using evidence n-levels removed from directly-relevant evidence, are in a way engaging in confirmation bias when they seek to use it as if it is direct evidence. I think it would be good to have some measure of how...

NAAFI tea was (and probably still is) a stalwart. Tea would go into a huge pot at the start of the day. Throughout the day it would be topped up with more water ... and more tea ... and more water ... and more tea ... etc. A glorious mix of fresh with the interminably stewed. Strong enough to...

I like my tea strong ... but not that strong!

Reminds me of how it apparently was before the railways in Britain, when the time was only roughly the same across the country. Towns and villages went by their own church clock, and it didn't really matter there was no universal agreement of any standard time. Once the railways arrived, with...

Indeed.

Yes I think we should, initially at least. Give them and the new editor in chief a fresh shot at it. If they blow it, so be it. This was my rationale ...

Ah, sorry. In that case I misunderstood @Sly Saint's post.

See quoted section in @Sly Saint's post ... https://www.s4me.info/threads/cochrane-review-exercise-therapy-for-chronic-fatigue-syndrome-larun-et-al-new-version-october-2019.11564/page-4#post-205847

Maybe cherry picked to help (still) support their findings? What difference would their have been without them? Were they within their remit to add these?

So would this rephrasing from your example also be correct? If there truly is no correlation between [Chemical A] and [Condition X], there would be a 1% probability that due to random chance alone, we would see a big enough difference between patients and controls to erroneously suggest there...