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News in Brief posts for w/c 22nd Jan. Facebook: https://www.facebook.com/sci4me/posts/pfbid0a2WnKzog3jgUtwLoHJFiv6aemHUFtmbp7e7szoaVBgyqh3FPhzi2YukgG5jQAFehl Mastodon: https://med-mastodon.com/@s4me/111833019631539136

Trial By Error: Debate Over Recent Citation of Arguably Fraudulent PACE Trial Professor Fedorovski et al conclude their response with this: “The jury is still out; we should wait for the verdict and respect it when it comes.” No, the jury is not “still out” when it comes to the PACE trial...

Some interesting use of language in this section as well. "PEM is a crucial source of suffering in the majority of ME/CFS patients" isn't how I would have chosen to describe it. My guess is that they are trying to say that PEM is a core symptom? "Fatigue pathology: MS, ME/CFS, Long COVID 1.4...

They also say this "Functional Somatic Disorders (FSD) refer to clusters of recurrent disabling bodily symptoms (e.g. chronic fatigue, pain) and are prevalent in all medical settings [1]. FSD cannot be better explained by other somatic or psychiatric condition and varies from mild to severe...

Abstract Objectives Earlier studies on the association between plasma lipid profiles and functional somatic disorders (FSD) are mainly small case control studies hampered by selection bias and do not consider the great overlap between the various FSDs. The aim of the present study was to...

"3.1. Myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS) ME/CFS is a serious, long-term, multi-system disorder characterised by a wide range of symptoms including extreme fatigue, autonomic and cognitive dysfunction, sleep disturbances and pain. ME/CFS affects motor, sensory and...

Highlights Though a common symptom, fatigue is difficult to define and investigate, and occurs in a wide variety of disorders, with differing pathological causes. This review aims to guide clinicians in how to approach fatigue and to suggest that neurophysiological tests may allow an...

10, 064 signatures at time of posting. https://www.change.org/p/cochrane-withdraw-the-harmful-2019-exercise-therapy-for-cfs-review

Opinion: The BBC and Dragons’ Den have let down ME patients https://inews.co.uk/opinion/bbc-dragons-den-let-down-me-patients-2875435

Prevalence of associated conditions and surgeries (click to expand) No mention of ME/CFS, or fatigue.

"Functional somatic disorder (FSD) is a unifying diagnosis that includes a range of functional somatic syndromes (FSS) such as irritable bowel syndrome, fibromyalgia and chronic fatigue syndrome, and it can be conceptualised as the diagnostic concept bodily distress syndrome.Reference Burton...

Full title: Neuroticism, perceived stress, adverse life events and self-efficacy as predictors of the development of functional somatic disorders: longitudinal population-based study (DanFunD) Abstract Background Functional somatic disorder (FSD) is a unifying diagnosis that includes...

ABSTRACT Purpose Treatments for myalgic encephalomyelitis and chronic fatigue syndrome can be adapted for post–COVID-19 condition. Our aim was to compare treatments in patients from our post–COVID-19 clinic. Methods We conducted a retrospective cohort study and included consecutive patients...

Thanks Wyva, I'll pass details on to the team. Here are further details about the project. Abstract While it is known that post-COVID-19-condition (PCC) is caused by SARS-CoV-2 infection, for most other immune-related noncommunicable diseases (IR-NCDs), no such infectious disease (ID) triggers...

@DMissa , is it this research that you will be talking about at UK: Conference: MitOX 2024, 12th April 2024

"Sixteen participants were recruited with a mean age of 53.6 years, ranging from 20s to 80s. All participants had completed at least high school education and 8 had each completed a bachelor’s degree. Most (13 of 16) were unable to work and most lived by themselves (11 of 16). Only 5 said they...

Abstract Objective To explore experiences of patients who have complex chronic conditions (CCCs), such as fibromyalgia and chronic fatigue syndrome, when they request medical assistance in dying (MAID) in Canada. Design Qualitative study using semistructured interviews. Setting Canada...

How does chronic stress harm the gut? New clues emerge Mental stress has long been linked to flare-ups of gastrointestinal conditions such as irritable bowel syndrome (IBS). Now, researchers have uncovered exact details of one way that stress can harm the intestines — by setting off a...

[In mice] Summary The brain and gut are intricately connected and respond to various stimuli. Stress-induced brain-gut communication is implicated in the pathogenesis and relapse of gut disorders. The mechanism that relays psychological stress to the intestinal epithelium, resulting in...

Abstract is slightly different to the preprint. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a frequent, debilitating and still enigmatic disease. There is a broad overlap in the symptomatology of ME/CFS and the Post-COVID-19 Syndrome (PCS). A fraction of the PCS patients...