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"Without the trillions of bacteria in the gut, muscles might not be able to knit themselves back together after an injury. According to a study published February 22 in Immunity, T cells that normally reside in the mouse colon play a crucial role in tissue regeneration—and rely on gut microbes...

Highlights Muscle injury induces local accumulation of RORγ+ Treg cells emanating from the gut The microbiota regulates muscle repair via RORγ+ Treg cells Muscle RORγ+ Treg cells shield differentiating muscle stem cells from IL-17A RORγ+ Treg cell emissaries play a general role in the...

Couple of social media posts if you want something easy to share. Facebook: https://www.facebook.com/sci4me/posts/pfbid031Qc4iFgXTSLeeo5Z4s3jGTkmux55rPnjHGodYXWPwXc35jEDU8DgWJjqKHFC4w6jl Mastodon: https://med-mastodon.com/@s4me/110128405809401848

News in Brief posts for w/c 27th March Facebook: https://www.facebook.com/sci4me/posts/pfbid02zLveB6dzRmbnaUzhcQt1PprfLseebzaap1ipMePWqfX6rcFSMkcSEPJTp7EQvhul Mastodon: https://med-mastodon.com/@s4me/110128997035687961

The full inclusion criteria can be seen here, https://mecfs.ctss.nih.gov/ The combination of, relatively, strict inclusion criteria and what they were asking from the patients in terms of attendance at the testing centre meant that they struggled to recruit participants and then seemed to...

Morten Group Oxford tweeted "Potentially very important paper. The release of mtDNA from the mitochondria appears key. Once this happens in a tissue, mitochondria loosing mtDNA will not be able to make ATP and likely targeted for destruction."

Yes, speak to your local university's sports science department to find out if they are able and willing. There is nothing unusual about the repeated CPET testing apart from the repetition, in most other circumstances only a single CPET is necessary. CPET itself is something done regularly.

Link to fundraiser page, https://crowdfund.berkeley.edu/project/37217 As in previous years, April is crowdfunding month at the University of California, Berkeley, and I am once again seeking funds to continue my work on ME, ME/CFS, “medically unexplained symptoms,” and now long Covid. These...

"Long COVID isn’t the first disease for which people have reported experiencing PEM. People who have myalgic encephalomyelitis, also known as chronic fatigue syndrome (ME/CFS), have long reported exacerbation of symptoms after overexertion that make their day-to-day functioning difficult...

Author list (my bolding of familiar names) Joel Selvakumar Lise Beier Havdal Martin Drevvatne Elias Myrstad Brodwall Lise Lund Berven Tonje Stiansen-Sonerud Gunnar Einvik Truls Michael Leegaard Trygve Tjade Annika E. Michelsen Tom Eirik Mollnes Fridtjof Lund-Johansen Trygve Holmøy Henrik...

Abstract Many individuals who had COVID-19 develop detrimental persistent symptoms; a condition known as post-acute sequelae of COVID-19 (PASC). Despite the elevated risk of cardiovascular disease following COVID-19, limited studies have examined vascular function in PASC with equivocal results...

Highlights Defibrotide is FDA and EMA approved for treatment of veno-occlusive disease. Veno-occlusive disease shares features of thrombotic microangiopathy including COVID-19. TMA and COVID-19 patient plasma induced endothelial cell activation/injury in vitro. Defibrotide blocked these...

March News in Brief post on Reddit. https://www.reddit.com/r/cfs/comments/128fimz/the_mecfs_and_related_news_in_brief_posts_for/

Video: Physics Girl & the Devastating Effects of Long COVID

Objective Women are reported to consult general practitioners (GPs) more frequently than men. However, previous studies on sex differences in help-seeking behavior for somatic symptoms do not distinguish between sex and gender, do not account for sex differences in presented symptoms, and are...

Background The high incidence of COVID-19 globally has led to a large prevalence of Long COVID but there is a lack of evidence-based treatments. There is a need to evaluate existing treatments for symptoms associated with Long COVID. However, there is first a need to evaluate the feasibility of...

Concerns regarding a suggested long COVID paradigm – Authors' reply "We thank the authors of these three helpful responses to our previously published Comment. 1 We welcome Fabian Schwendinger and colleagues highlighting some important factors related to the ongoing immune response that we did...

Concerns regarding a suggested long COVID paradigm, van der Palen "Upon reading Chloe Saunders and colleagues’ Comment, 1 it is striking how this new paradigm is essentially the old paradigm for medically unexplained symptoms and contested illnesses. 2 The authors advance an alleged...

Abstract Objective and design: Fatigue is a prominent symptom in the general population and may follow viral infection, including SARS-CoV2 infection which causes COVID-19. Chronic fatigue lasting more than three months is the major symptom of the post-COVID syndrome (known colloquially as...