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References the Cochrane review on exercise. "Attempts made, even in recent years, to define the impact of physical activity as a therapy, at least adjuvant, in patients suffering from MC/CFS, have highlighted that contradictory results worsen patients’ capacity to adequately perform daily...

Purpose Return to work (RTW) may be facilitated by motivational interviewing (MI), a counseling style designed to increase motivation towards behavior change. MI’s relevance in a RTW context remains however unclear. Exploring how, for whom and in what circumstances MI works is therefore...

"Everyone knows what attention is and no one knows what attention is Over the course of time and across different disciplines, attention has been addressed and presented with many definitions (246, 247). Interestingly, it has been defined as the process that enhances representation of some...

This is a study from 2016, so I'm just posting it in order that we have it here on the forum.

Significance Chronic fatigue syndrome is a multisystem disease that causes long-term pain and disability. It is difficult to diagnose because of its protean symptoms and the lack of a diagnostic laboratory test. We report that targeted, broad-spectrum metabolomics of plasma not only revealed a...

We review the neurobiology of Functional Neurological Disorders (FND), i.e., neurological disorders not explained by currently identifiable histopathological processes, in order to focus on those characterised by impaired awareness (functionally impaired awareness disorders, FIAD), and...

"The arguments in favor of a neurologic reclassification of FND The prevalence of patients with FND or Medically Unexplained Symptoms (MUS, including fibromyalgia, chronic fatigue syndrome, and reflex sympathetic algodystrophy/causalgia) in neurology clinics is estimated to be around 16–30%...

Full title: Functional Neurologic Disorders, disorders to be managed by neurologists, or are neurologists wandering in a dangerous field with inadequate resources? In recent years, some neurologists reconsidered their approach to Medically Unexplained Symptoms and proposed Functional Neurologic...

Background Long COVID symptoms occur for a proportion of acute COVID-19 survivors, with reduced risk among the vaccinated and for Omicron compared with Delta variant infections. The health loss attributed to pre-Omicron long COVID has previously been estimated using only a few major symptoms...

Abstract To assess biobehavioral sex differences in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) utilizing a low burden exercise protocol, 22 females and 15 males with ME/CFS and 14 healthy controls underwent two six-min walk tests. Fifteen daily assessments were scheduled for...

Twitter thread from one of the authors.

Abstract Since its first identification in Scotland, over 1000 cases of unexplained pediatric hepatitis in children have been reported worldwide, including 278 cases in the UK 1. Here we report investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised...

Trial By Error: New JAMA Article Seeks to Revive the Zombie Case Definition for CFS from 1994 "The long Covid narrative seems to bounce back and forth with each new study or review documenting contrasting findings—evidence of serious pathophysiological anomalies among sub-sets of patients...

From an NIH MECFS Information List email, "NIH’s next ME/CFS Advocacy Call will be held on May 1, 2023 from 12:00 – 1:00 pm ET. The webinar will include updates from NIH on ME/CFS-related research activities and a scientific presentation by Avik Roy, PhD, and Gunnar Gottschalk, PhD...

Exciting, and relieving, to get to this next step. "The first batch of DNA from #DecodeME participants is on the way to @thermofisher to begin analysis. Thank you to for all the recent positive messages. It’s great to see this stage of the study get going! #pwME #MECFS There is still time to...

"If you pay for NHS prescribed HRT medicine 3 or more times in 12 months, an HRT PPC could save you money. Each item on an NHS prescription usually costs £9.65. You can buy an HRT PPC for a one-off payment of £19.30 (the cost of two single items). The HRT PPC covers an unlimited number of...

Full title: Trajectories of health-related quality of life and their predictors in adult COVID-19 survivors: A longitudinal analysis of the Biobanque Québécoise de la COVID-19 (BQC-19). Purpose A significant number of people will experience prolonged symptoms after COVID-19 infection that will...

Corrigendum to “Chronic Fatigue Syndrome (CFS) symptom-based phenotypes in two clinical cohorts of adult patients in the UK and The Netherlands” The authors regret that there was an error in the Ethics Statement. The corrected Ethics Statement as follows: The UK CFS patient data were collected...

Published papers thread. Mastodon: https://med-mastodon.com/@s4me/110133854392486824 Facebook: Not sure there will be one as Twitter's Thread Reader App doesn't seem to be working.

Significance ACh-releasing choline acetyltransferase (ChAT)+ T cells promote vasodilation and regulate blood pressure in mice, but human ChAT+ T cells and the molecular mechanisms by which ChAT-expression is regulated remain undefined. In this study, we identify primary ChAT+ T cells in patients...