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Abstract The Coronavirus Disease 2019 (COVID-19) has affected all aspects of life around the world. Neuroimaging evidence suggests the novel coronavirus can attack the central nervous system (CNS), causing cerebro-vascular abnormalities in the brain. This can lead to focal changes in cerebral...

Discussed here, https://www.s4me.info/threads/article-we-might-have-long-covid-all-wrong-covers-fnd-me-cfs-includes-sharpe-garner-carson-and-more.30818/page-7#post-458187

Other aspects that I think need to be factored into the conversation around patient and carer involvement are: 1. The reduction in community capacity that might happen when an advocate is involved in a research project. For patient communities that have a more established and extensive pool of...

I would also add to this "If you think that you completed the DecodeME questionnaire but didn't answer 30+ questions, then you will have signed up to receive updates from us but not taken part in the study itself." There are still a considerable number of people who signed up to receive...

Our latest post on social media: "If you’re taking part in DecodeME, here’s your gentle reminder to make sure that you’ve completed the steps you need to. If you’re completing the questionnaire, don’t forget that you can save your progress and return to your responses at a later time. This...

DecodeME certainly combines research with advocates (patients and carers). We are a research project so our principle aim is obviously to recruit as many pwME to the project as possible and then deliver the analysis of the questionnaire and genetic data that we get, but in promoting the study we...

Full title: Severe Fatigue and Persistent Symptoms at Three Months Following SARS-CoV-2 Infections During the Pre-Delta, Delta, and Omicron Time Periods: A Multicenter Prospective Cohort Study ABSTRACT Background Most research on SARS-CoV-2 variants focuses on initial symptomatology with...

"The strongest association for time-on-task effects was linked to problems with fatigue in daily life, for which there were widespread BOLD increases in cerebellar, occipital, and prefrontal areas with longer time on task. Heightened task-related BOLD activity has previously been observed in...

Abstract This study investigated how proactive and reactive cognitive control processing in the brain was associated with habitual sleep health. BOLD fMRI data was acquired from 81 healthy adults with normal sleep (41 females, age 20.96 - 39.58 years) during a test of cognitive control (Not-X...

If you believe that over-exertion in people who experience PEM is potentially harmful, which I do, then I believe that the ethics of a study which asks people who experience PEM to over-exert themselves is always going to be problematic. I doubt that this study explicitly says "we will be...

From the trial listing, "Intervention Behavioral: Internet-delivered treatment: "One step at the time" The guided internet treatment program consists of 11 modules (+ 1 module for relatives) activated consecutively over a period of 14 weeks. The content is written psychoeducation, patient...

"Gain-of-function research (GoF research or GoFR) is medical research that genetically alters an organism in a way that may enhance the biological functions of gene products. This may include an altered pathogenesis, transmissibility, or host range, i.e., the types of hosts that a microorganism...

Is one interpretation, I personally was glad to see this exclusion so that people with PEM aren't harmed.

Abstract Introduction Studies exploring alterations in blood coagulation and platelet activation induced by COVID-19 vaccines are not concordant. We aimed to assess the impact of four COVID-19 vaccines on platelet activation, coagulation, and inflammation considering also the immunization dose...

"Participants—eligibility criteria Participants are eligible if they were admitted to hospital during the acute phase of their COVID-19 confirmed (by PCR) or clinician diagnosed COVID-19 and have ongoing symptoms lasting more than 12 weeks, with no upper limit, that may be modifiable by a...

Full title: The effect of COVID rehabilitation for ongoing symptoms Post HOSPitalisation with COVID-19 (PHOSP-R): protocol for a randomised parallel group controlled trial on behalf of the PHOSP consortium Abstract Introduction Many adults hospitalised with COVID-19 have persistent symptoms...

Related publication, Internet-delivered treatment for patients suffering from severe functional somatic disorders: Protocol for a randomized controlled trial 2023 Fink

Highlights • This is the first e-based treatment for severe functional somatic disorders. • Two active conditions, a guided and an unguided treatment program, are compared. • We expect both programs will prove effective in enhancing physical health. • We hypothesize that the guided program will...

Following an acute COVID-19 infection, a large number of patients experience persisting symptoms for more than four weeks, a condition now classified as Long-COVID syndrome. Interestingly, the likelihood and severity of Long-COVID symptoms do not appear to be related to the severity of the acute...

Abstract Postacute sequelae of SARS-CoV-2 infection, commonly known as long COVID, is estimated to affect 10% to 80% of COVID-19 survivors. We examined the prevalence and predictors of long COVID from a sample of 1,338 COVID-19 cases among university members in Washington, DC, USA, during July...