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They probably liked the short online CBT intervention because it required the least effort out of these useless treatments.

I'm not opposed to the idea as I think it is clearly true that the feeling of PEM, just like fatigue and pain, must be produced within the brain. However, my pushback is that rouge neuronal firing doesn't really clarify the problem for me. If we think about what a theory of ME/CFS should...

How much energy does it take for T cells to proliferate? It is plausible to suggest that the proliferation of a certain type of immune cell has a non-negligible impact on overall energy use? I have always found it hard to believe that this type of energy consumption could be anywhere near the...

I think that is a very important point. I used to be sure that cognitive exertion itself could drive symptoms. However, I have realized that I am often sitting upright and have an increased heart rate when exerting in this way. It is also hard for a study to separate these forms of exertion as...

Didn't watch the presentation but I did see that at least one, if not more, of the controls were closely related to the participants. Given that there is likely a genetic component to these conditions, this might explain why such a high proportion of healthy controls had orthostatic symptoms in...

That is an important point. Even if we get good evidence that this is occurring in ME/CFS it may be the case that it is a response to another issue. One could imagine that vascular/orthostatic issues could cause microglia to become activated. If that's the case, treating the activation directly...

I assume it also regulates brain temperature as heat can't effectively radiate through the skull

My thinking on this is that there is a group of symptoms that occurs from exertion in ME/CFS. There is also a group of symptoms that occurs when sick and particularly when exerting when sick. Mij you clearly think these two things are completely separate and because ME/CFS is likely not one...

Did you try to exert yourself while you were infected? Also I presume you had ME/CFS at that point so that makes it a little hard to figure out what is related to the infection and what is related to ME/CFS. I think people certainly can have cognitive symptoms after exertion when sick...

How similar is PEM to how one might feel after they exerted themselves during a bad infection? I'm trying to think back to when I had an infection pre-ME/CFS, but it is hard for me to think of an example where I didn't try to rest when quite sick. There differences like fever which don't...

This is the study mentioned by Younger in his most recent video. Couldn't find a thread on this paper.

In this pilot study, a human intravenous injection of low-dose endotoxin (lipopolysaccharide, LPS) model was used to test if fibromyalgia is associated with altered immune responses to Toll-like receptor 4 (TLR4) activation. Eight women with moderately-severe fibromyalgia and eight healthy...

The idea of measuring the signaling response to a stimuli is a good way to go about this. If there ends up being a signaling problem, there has to be some reason that the signal is present. Even if the signal is erroneous there must be some reason why it is happening in the first place. If we...

What about a shift in how certain brain cells are utilizing energy. If there is some subtle shift in the way energy is generated perhaps cells wouldn't demand as much oxygen to replenish their supplies. This could also lead to a decreased BOLD fMRI signal.

It must also be the case that almost everyone is using the term incorrectly. Most of the websites I have visited suggest that FND is due to some brain mismatch or software issue. If this were the case then these people wouldn't have FND they'd have some other issue.

Ahh ok I understand the nuance now. People with FND do not have any pathology but only in a definitional sense. It is impossible to have FND and also have some pathology. Of course, there is some unknown pathology so the label is only useful in acting as a waiting zone. Once we have a better...

I thought we agreed that FND is a label to describe a condition where some symptoms can not be currently be attributed to some identifiable process. If FND excludes any biochemical process in perpetuity, then it can not exist by definition. How can something within the universe happen without a...

Some threads discussing papers which showed abnormal brain lactate: https://www.s4me.info/threads/multimodal-and-simultaneous-assessments-of-brain-and-spinal-fluid-abnormalities-in-cfs-effects-of-psychiatric-comorbidity-2017-natelson-et-al.37784/#post-522553...

I don't think it was expected to be a cure for GWI. Even finding a treatment helps with symptoms can be useful and tell us something about what is going wrong. There aren't really any proven treatments to reduce TSPO activation otherwise they would have been tested in clearly neuroinflammatory...

How about idiopathic non-epileptic seizures? Because we don't know the cause of FND, I don't think the label should be particularly specific. I think a label that implies a neurological problem of some unknown cause is most appropriate. As with any idiopathic condition, we don't have to list out...