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Has the role of NO linked gene expression been considered relative to instigatng bistability in IDO1/ IDO2 pathways? My understanding is that NO inhibits IDO activity by preventing oxidixation of TRP Is this a link to the sepsis similarities?

interesting link to roles and mechanisms of IDO 1 , IDO2 and TDO https://pubs.rsc.org/en/content/articlelanding/2017/mt/c7mt00105c#!divAbstract

I hope I have not mislead/ confused. I don't t know if Craig Robertson has pitched this molecularly. It simply strikes me as an explanation for the relapse and remitting aspect and the similarities re catastrophe/ instability are striking, even to a non mathematician. Interestingly similar...

Sort of like inverse obesity with grehlin and leptin signalling gone awry?

Does " Montgomery v north lanarkshire" ruling apply to physios ? The physio we saw was completely uninformed re ME, conflated with chronic fatigue, no knowledge of use of hear monitors, oi issues, what PEM actually is. When is lack of knowledge a defence when there is so much info outside their...

Microchips for alzheimer's- interact with heating system and avoid use of manual controls to provide suitable temperature - this has already been proposed (!) ( my cousins daughter has her art masters portfolio on a microchip in her hand - her theme was cybernetics) Smart meter data has...

Check out Craig Robinson's maths catastrophe theory as applied to ME

A number of interesting comments now, including further contributions from @Jonathan Edwards .

thank you - from someone with 2 family members significantly affected this means a lot.

how any jenga bricks will it take?

Has degree been modelled - ie upstream and downstream effects of various levels of inhibition of various cell types susceptible to the "trap"; this is a systems condition - it is how this may affect other processes and mechanisms by degree that is the interesting bit. It never ceases to amaze...

The prose, as ever, is beautiful. The sense of loss is tangible. The oxymoron of happiness and grief a poignant reminder of how much this illness strips away. I'm so glad you have managed outside, it gives those in gilded bedroom cages hope. Thank you.

Magnesium is the one supplement that is instantly noticeable if we miss it. It is key to so many reactions. Lower core body temperature probably doesn't help either

Sorry to hear this @Sarah94 . We had a close relative who was entirely disbelieving until they watched Unrest. ( it is a good advocacy film for general public) That said they now feel awkward and don't engage much.

Future proofs your home - you are not the only one who may use it. Promotes independence and underpins potential for improvement for you - the avoidance of PEM may help you even out a activity and actually achieve more in the long run

Signed

this

Before I knew anything of this illness, and the politics engulfing it, I was annoyed that there were no specialists anywhere near us. Now i realise that we are in a better place than many others. ( and the current place is not too good) . I now have knowledge and my daughter understands her...

Thanks- I obviously didn't t read the paper.

I wonder what would have been found 3/ 4/ 7 days after.PEM may start on 2nd day but may be nowhere near its peak.