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    Glycolytic impairment - what are the practical implications?

    would insulin resistance not also affect leptin and grehlin signalling and thus the hunger response- body has lost calibration of satiety?
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    News about Long Covid including its relationship to ME/CFS 2020 to 2021

    piece in Washington Post by Julie Reymeher, Jen Brea and Brian Vastag https://www.washingtonpost.com/health/long-haul-covid-patients/2020/10/23/ab7c5324-0712-11eb-9be6-cf25fb429f1a_story.html?fbclid=IwAR3bJ6QHbmTMzkg9YV6jEybvkGPpAgstVE0EdrCGbezeO9E6PArfTML57KY&mc_cid=a292066a60&mc_eid=7dd94a557c
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    Do treatments for paediatric chronic fatigue syndrome improve pain? a systematic review, Ascough et al, 2020 G535(P)

    Each paper simply reinforces how little such pediatricians actually know. For any to be termed " expert" is denigration of the term
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    Therapists’ perceptions of barriers and facilitators to uptake and engagement with therapy in long‐term conditions - Oct 2020 Moss-Morris et al

    Yep , had to fight to stay awake in that lecture
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    Substrate utilisation of cultured skeletal muscle cells in patients with CFS, Tomas et al, 2020

    Apologies if this sounds garbled ( and it could well be wrong ) , I looked at PPP some time ago when.looking at D Ribose as a means of reducing PEM. Is the pentose phosphate pathway more energy intensive ? Ie net energy deficient and takes some time to generate ATP.
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    Early Growth Response Gene Upregulation in Epstein–Barr Virus (EBV)-Associated ME/CFS, Kerr, 2020

    I have no doubt psychological stress can play a role, but THE role ? PEM inducing stresses would seem more likely, especially if in a state of rolling PEM.
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    Substrate utilisation of cultured skeletal muscle cells in patients with CFS, Tomas et al, 2020

    Thanks @Midnattsol . I wondered if the lack of ATP upstream caused a mitochondrial feedback loop. One complex is overproducing because the other is under producing .
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    Substrate utilisation of cultured skeletal muscle cells in patients with CFS, Tomas et al, 2020

    It would be useful to know how many were female - other studies have flagged up a propensity for females to switch to aminos in preference to fat . Also AMPK is a key signalling molecule which seems to have many functions , it modulates metabolism in many conditions including diabetes ...
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    NICE ME/CFS draft guideline - publication dates and delays 2020

    This
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    Substrate utilisation of cultured skeletal muscle cells in patients with CFS, Tomas et al, 2020

    Would you not need to do this to avoid being in a catabolic state?
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    Substrate utilisation of cultured skeletal muscle cells in patients with CFS, Tomas et al, 2020

    Does this tie in with the mismatch between complex 1 and complex V in mitochondria reported previously by others ?
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    News about Long Covid including its relationship to ME/CFS 2020 to 2021

    Everyone else has to improve their " resilience" , or in other words it's your own fault if you can't cope. A get out clause for employer and workforce/ work dynamics. This has been the buzzword/ favoured instigation for recent years.
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    The peri-menopause in a woman’s life: a systemic inflammatory phase that enables later neurodegenerative disease, 2020, Raval et al

    at the other extreme - given one of the female spikes for incidence is puberty - does the rise in estrogen in puberty have some significance re immune function that may contribute to onset?
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    Does the new ME/CFS research of BPS proponents affect anything much now?

    This
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    Chronic fatigue syndrome/myalgic encephalomyelitis in children aged 5 to 11 years: A qualitative study, 2020, Bridgen, Crawley et al

    You can drive a horse and cart through most of the papers quoted. The concept of an asymmetric power relationship seems lost. When you have the very real consequences of failure to attend, an expectation of progressive, linear improvement , and so little understanding , diaries...
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    Preventing Post Exertional Malaise - online talk with Staci Stevens and Dr Mark Van Ness - Thurs 22nd Oct 2:30pm

    Thank you for this, forwarding on to long C OVID Swedush relatives for some useful input .
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    CBT combined with music therapy for chronic fatigue following Epstein-Barr virus infection in adolescents: a feasibility study, 2020, Wyller et al

    Virtually all paediatric research is CF
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    Preventing Post Exertional Malaise - online talk with Staci Stevens and Dr Mark Van Ness - Thurs 22nd Oct 2:30pm

    Brilliant thanks
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    BACME: Position Paper on the management of Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS), Oct 2020

    The king is dead... long live the king
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    Preventing Post Exertional Malaise - online talk with Staci Stevens and Dr Mark Van Ness - Thurs 22nd Oct 2:30pm

    Will this be recorded to view later? Unfortunately will be out on Thursday afternoon.
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