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Abstract T cell exhaustion limits effector T cell function in chronic infection and tumours. The development of these hypofunctional T cells and of their precursors was considered to require stimulatory conditions that are met only after persistent exposure to antigen and inflammation. Here we...

Continuing the through line - both Ley Sander and Suzanne O'Sullivan are consultants at the UCLH Epilepsy service. Suzanne O'Sullivan features in the psychosomatic section of this forum. Penguin books says this about her:

If rubbish is the input, it takes a lot of effort to not produce more rubbish. Looks like this team took the easy route and produced more rubbish. I'd use the analogy of not spinning straw into gold, but in fact I think that's what the whole psychosomatic industry does. They take studies that...

Thanks to all the posters. That's looking pretty worrying for ME/CFS and Long Covid care in Scotland - possibly many steps backwards?

This thread is to make it easier to find forum information about subjective survey tools. These tools are used to quantify concepts such as fatigue and quality of life for use as subjective outcomes in research and clinical monitoring. The list will be added to over time. This thread is pinned...

See my post just before yours. It's worth clicking through to the MEA document, but 'remote assessment' is still vague. A video call?

Posts moved from the News from Scotland thread That reads oddly - it makes it sound as though the multidisciplinary team will be assessing everyone including Glaswegians primarily through remote assessments in the Highlands. I imagined a retreat with the physio and the OT at some remote but...

And this paper could be used to support something around that idea. Because it found that people who had been ill longer had the highest chance of having come to terms with the illness and having adapted to it. That's hardly rocket science (and ignores survivorship bias in the people who are...

While I have problems with the concept of Dysautonomia, after a quick skim, I thought this paper was ok. It would probably help a counsellor have some ideas about how to work with a person who has Long Covid. It acknowledges the reality of the symptom burden throughout, and does not suggest...

They did statistical tests seemingly on everything they could think of, but little was different and even less survived correction for multiple testing. There were statistical tests on things like peak value attained (but the 15 minutes between tests means that peaks may have been missed) and...

Gosh, Arroll really is persistent. Thread on the paper here

I'm a bit bemused by the definitive way the results are presented here. I mean, they looked at 58 people with ME/CFS and they didn't tell us about the severity of the participants in the abstract. That hardly qualifies them to make a statement about all people with ME/CFS. If they had chosen...

Thanks for the summary SNT, that's extraordinary. Except it probably isn't :(

There's the question of whether the response of the CFS group is abnormal. Given the considerable overlap in results between the two groups, I very much doubt that it is. Yes, the differences are indeed subtle and only apparent at the group level. The differences are not diagnostic. Yes...

Method Results Jumping to the result that made the abstract (because everything else was unremarkable) ACTH response to vasopressin infusion Note that the error bars are Standard Error of the Mean rather than Standard Deviation. SEM is SD/square root of the number of samples, so SEM is...

Thanks to the member who sent me a copy. About the CFS participants: While that paragraph illustrates the mis-labelling that has gone on of people with fatigue, I think it, together with the loose CFS criteria, does raise more concern that this study may not be very useful in telling us about...

So, would the following be accurate? Although the side effects of aripiprazole are frequently significant and occasionally very serious indeed, the 15 to 20 year reduction in life expectancy for people with schizophrenia using antipsychotics will be the result of a number of factors. Those...

A small 2001 study Abnormalities in response to vasopressin infusion in chronic fatigue syndrome Not significantly different.