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Given everything the admin has said about reorg and priorities and their actions so far, people should expect more than not that RECOVER will end

Devastating if this is true. They are terminating the entire RECOVER initiative right in the middle of it!! https://cen.acs.org/policy/research-funding/NIH-cancels-RECOVER-grants-long/103/web/2025/03 This hasn’t hit mainstream media yet we will see a lot more news on it very soon

https://www.biopharmadive.com/news/sanofi-dren-deal-bispecific-myeloid-cell-engager-autoimmune/743041/

I’m in a similar boat as you. LDA will work incredibly well for me at first but slowly lose effectiveness and ME symptoms increase again over the course of many months. I usually take it for 6 months at a time and been taking 6 month breaks until I can cycle back on it. If you only took it for...

https://www.gavinpublishers.com/article/view/long-covid-patients-successfully-treated-by--means-of-heparin-mediated-extracorporeal-ldl-precipitation-help-apheresis Many COVID-19 infected patients develop a chronic state of disease that hinders them for months or even years due to severe...

https://undark.org/2024/05/20/bad-blood-microclots-long-covid/

One thing to mention is one worry I have about HCQ is that it can cause herpesvirus reactivation. I’m in the subset with definite lab evidence suggestive of viral reactivation. It’s the age old ME question, for those of us with evidence of herpesviral (EBV, CMV, HHV-6) reactivation (in my case...

I really hope HCQ will make some difference in my ME symptoms. I’ve never trialed it. Even if I test positive for lupus and am diagnosed with lupus the soc is also HCQ unless it by itself can’t control flare ups and organ damage. But if I do have lupus so many ME symptoms overlap with lupus...

This is possibly an important factor for a subset of pwME. I actually had some revealing blood tests recently that were surprising. Had surgery in Nov and during the pre-op testing they found a coagulation abnormality in my blood, my APTT (also called PTT) was very high. Then they ran a bunch of...

I thought measuring IgG in this study was to have a proxy measure of plasma cell depletion and therefore aberrant IgG autoantibodies potentially driving ME?

People get very sick and die from COVID because their immune systems go haywire in response to the virus. Inflammation is only good in the beginning but continued hyperinflammation and immune dysregulation causes damage and possibly death

Coincidence? https://www.s4me.info/threads/aripiprazole-abilify.16972/page-11#post-326818

And for some reason they are able to definitively show causation that the cause was taking LDA and not just getting worse because ME will do that and taking LDA was just bad timing making the correlation look like causation? The FBK LDA group tends to be quite ill-informed on a lot of things.

To me and many others it’s the $64m question. I’ve continued to get similar incredible benefits from LDA but it requires a many months long break in between after it poops out until it starts working really well again. I did another cycle this year for 7 months. I went on a long vacation with a...

For almost every FDA approved drug one can find a big enough group of people saying the drug made them worse. Take GLP-1 drugs for example, which have been prescribed for over 10 years now, they are some of the most efficacious and safe drugs ever created yet still even after countless large and...

Dopamine and serotonin are important players in immune system regulation and function Dopamine, Immunity, and Disease https://pmc.ncbi.nlm.nih.gov/articles/PMC9832385/

Well yes because but this study is talking about COVID mortality, not improvement in ME symptoms. We’ve also discussed at length here and elsewhere the reasons why even much lower dosages aripiprazole are still quite potent (eg dopamine system interactions at low dosages and high occupancy) The...

https://www.nature.com/articles/s41598-024-60297-y

Again, it doesn’t mean it’s just some nebulous idea, each varying definition is clearly based on a signature of measurable phenotypic markers