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Assuming Cort Johnson's source is reliable, this is worrying. This means the basis for rejecting the grant application wasn't the science behind the diagnostic test -- which must have been solid enough to reach the last round of reviews -- so any change of methods post-review won't help it be...

To the best of my knowledge, the three largest groups of ME/CFS patients in France are Pr Authier's in Paris, Dr Ghali's in Angers, and that of Dr Retornaz and Pr Jammes in Marseille. The latter two are the only ones to research ME in France (Authier instead works with EUROMENE). Very glad to...

@Chris Ponting Have you seen this paper by chance? These findings from Selin and Gil's group seem very relevant to your presentation at CMRC2020 on T cell clonality as a potential biomarker for ME/CFS. The research study abstract for their Solve ME Ramsay award can be found here...

Pre-print, not peer-reviewed. Physical activity measures in patients with myalgic encephalomyelitis/chronic fatigue syndrome: correlations between peak oxygen consumption, the physical functioning scale of the SF-36 questionnaire, and the number of steps from an activity meter Rowe PC, Campen...

That makes sense. The fact that the small sample size brought out these irrelevant associations goes to show how important carrying out a wide scale GWAS is. Thank you for your work! :) ETA: Would it be worth it to send a reply to the editor to point out your finding?

Were the associations checked against all UK Biobank patients or only those who reported an infectious onset (if the biobank records this data)? From the abstract (bolding mine):

This is the only sensible way forward. While that would be a welcome development compared to past times, NIH grant approval rates are not going to go up no matter how much ME patients advocate for it -- but teaming up and gathering resources for wide studies may compel NIH grant reviewers to see...

I'm confused about what the money raised will go towards. Does it fund @dave30th's position as an employee of UC Berkeley or does it fund Trial by Error as a project? It seems to be the former according to the description on the crowdfunding page, but paying one's employer sounds strange. On...

Carmen Scheibenbogen has been looking at antibodies against beta-adrenergic and muscarinic cholinergic receptors in ME/CFS since at least 2016 (https://www.sciencedirect.com/science/article/pii/S0889159115300209). The results have been interesting. Charité Berlin is the biggest ME/CFS hub in...

I hope this went well!

Meeting went south because of Koroshetz, according to Claudia Carrera. She says she’ll upload the audio shortly. Comments by Jen Brea (did not attend the call I believe), click on her tweet to see her further replies

Ron Davis and his team intend to to track post-COVID19 cases of ME/CFS.

This is a paper by one of the EUROMENE working groups. You would think that, by now, they would have realized that ME/CFS research requires innovative ideas rather than repeating the same old studies. Replicating results from studies proposing a potential biomarker is definitely important, but...

I remember reading CNN's piece on his story (https://edition.cnn.com/2019/07/27/health/doug-lindsay-invented-surgery-trnd/index.html). Adrenal dysfunction is a major problem, but is there any previous study or data that would point towards it in ME?

Indeed. The IOM committee probably wanted to insist on the biological nature of ME, and using "exertion intolerance" instead of "fatigue" also subtracts many possible (but maybe not all) psychological/psychiatric interpretations of the disease. In that sense, SEID clearly is a better term than...

Besides the classification issue with SEID (or lack thereof) that @Dx Revision Watch described very well, two things to note: - intolerance to exertion is not specific to ME, it also happens in severe forms of a number of diseases: myopathies, COPD, cardiovascular & genetic conditions... -...

Thanks for letting us know :) Looking at this list of neurohormones, issues with releasing and neurohypophysial hormones can arguably be ruled out. Otherwise blood tests would show them in most people with ME. This leaves us with two interesting categories: - adrenomedullary hormones...

I'm not sure what mito fission tells us in the context of ME. Relevant:

Yes, Prusty became quite active on Twitter when the fundraiser began. Not too sure what to think of it. As long as his findings are solid, I don't necessarily see him providing insights into his research as a "wrong" way to boost the fundraiser. But it's irresponsible of him if he knows his...