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This is from the team at Roskamp Institute that has a NIH R21 exploratory grant for investigating the "Application of lipidomics to identify biomarkers of immune and mitochondrial disturbances in chronic fatigue syndrome". Nancy Klimas is a co-principal investigator on the grant...

Merged thread Ingrid G. Rekeland 1, Alexander Fosså 2, Asgeir Lande 3, Irini Ktoridou-Valen 1, Kari Sørland 1, Mari Holsen 4, Karl J. Tronstad 5, Kristin Risa 1, Kine Alme 1, Marte K. Viken 3,6, Benedicte A. Lie 3,6, Olav Dahl 5, Olav Mella 1,5 and Øystein Fluge 1,5* 1 Department of Oncology...

The press article has been updated with the estimate of EUR 40bn/year and it links to the EUROMENE study. Great & quick response from the press officer Yasmina Yakimova.

Thank you for the summary Michiel. OK, that is a sensible idea. Needs funding though, and that draws away from biomedical research funding which is already very scarce. Many patients from countries where CFS is the commonly used denomination don't know about the term ME and get confused...

Today is the last day to contact your MEPs. Below is a mail you can copy and paste, just replace everything between brackets. You can find the mails of MEPs from your country who sit on the PETI committee here: https://www.europarl.europa.eu/committees/en/peti/home/members Google Translate or...

Not a fan of the hype around this paper. It's a big hypothesis ontop of preliminary data, yet the media/PR person at UCSD who wrote the press release for the article embellished/extrapolated the results. Let's not forget that a year ago, the Science Media Centre in the UK was very keen to point...

Other concerns in the study and its associated press release raised by Van Elzakker and Proal (both from the Polybio foundation).

Besides this study and other ones on mitochondrial dysfunction in ME/CFS, there also was an update from NIH on their intramural study in January. While it's still in PBMCs, it hopefully is good quality data -- that would strengthen the possibility of mitochondrial dysfunction in ME. Source

Caniocervical and/or atlantoaxial instability cause brainstem compression (brain's motor center) and can result in ME/CFS symptoms. Judging by that example, I would assume the fatigue and weakness to be similar to ME/CFS. Other diseases like Chiari malformation and syringomyelia do cause severe...

Yes! Could an abnormality in the liver or muscle happen in PBMCs too, but to a lesser extent, or would it be detectable exclusively in those tissues? If there effectively is a "factor in the blood" that floats around, I am thinking that it could affect different types of cells, but not in a...

Thanks for pointing that out. I dismissed it as "it's only 8 out of 20 patients", but could that finding isolate at least a subset of patients? In his presentations at NIH'19, Prusty also mentioned similar small non-coding RNAs from other viruses. I wonder if checking for all of these sncRNA...

I understand the link/their hypothesis as: "Secretions from cells infected with HHV-6A and ME/CFS serum have the same effect(s) in our experiments, so they share the compounds that cause these effects". Per the abstract (spacing mine): I couldn't find where they start justifying this link...

Seems to be underway. I believe the recently completed fundraiser for Prusty is meant to help him with developing and assessing that test, as it kicked off in February while the paper was submitted in late January. It will be a while until this test is finalized, reviewed and published though...

They address the interferon-type response in the last paragraph. Hopefully that is enough to rule it out.

Is Prusty agreeing with you on the "antiviral phenotype"?

Agreed. Publishing papers sounds like a waste of time to many of us because it takes time and slows down progress in the lab (in normal times), but if it's the key to obtaining grants... it's a necessary "evil". Even then, though, NIH grant reviewers have to assess the quality of the published...

Not an unpopular opinion -- it's a fair criticism and a possible explanation. However, Ron Davis has received big grants throughout his career so he should be well aware of the gotchas of writing grant applications. I wouldn't expect him and his colleagues to forget to outline the benefits of...

This is disheartening. The best thing we can hope for is that the reviewer who made that comment won't be on this year's ME/CFS SEP committee, but I don't know if the committee is renewed every year.

Unfortunately, these rejected applications did go to the CFS SEP, and they were recent (from the last cycle -- 2019?).