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Just a small typo, there were 29 male patients.

In France, the minister of health, a neurologist, was interviewed on national TV last night. He stated that people seemed to be mostly affected by cardiac and neurological issues (and post-viral fatigue in a previous interview) and says that researchers are looking into dysautonomia. This is...

Davido, B., Seang, S., Tubiana, R., & de Truchis, P. (2020). Post-COVID-19 chronic symptoms: a post-infectious entity?. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, S1198-743X(20)30436-5. Advance online...

Neuroinflammation? Referring to VanElzakker's paper [1] (esp. Table 1) for studies that found significant differences between ME/CFS vs. control groups (not listing others). [1] VanElzakker MB, Brumfield SA and Lara Mejia PS (2019) Neuroinflammation and Cytokines in Myalgic...

The article is excellent and it's amazing to see so much research into the sequelae of COVID19. My hope is that the pathophysiology of these long-term symptoms, although caused by COVID19, does not differ much from that of long-term symptoms in other viral infections (e.g. EBV) -- and thus the...

Actually, they do cite the latter... Not sure they read it!

Great :) I’m not an expert in hypothesis testing/statistics, but this means it has sufficient statistical power? Two more things: - Analyzing subsets would be interesting! For example, if a genetic predisposition to ME is identified in participants without an Ehlers-Danlos syndrome (EDS), it...

Absolutely delighted by this good news. A big, warm thanks to everyone involved! :) A question: recruited participants will (normally) all be from the UK, but the NHS apparently do little testing before establishing a diagnosis of ME/CFS. A non-negligible amount of patients who have not been...

Dr Systrom is looking into heart preload failure by using invasive CPET. His findings have been conclusive so far. Hopefully the red blood cell deformability experiment at Stanford can tell us more. I think Claus Wirth is investigating this with Carmen Scheibenbogen.

By weight, from the study: With this huge quantity of curcuma, the improvements in most mito-related measurements between mice w/ CKD and CKD+Cur were in the range of 20-50% (or a little more in Figure 2). Admittedly though since @MicrobiomDigest and PubPeer have torn down papers from...

Leonard Jason and his team at DePaul University look into key community-based (demographic, social, psychological) aspects of ME/CFS that remain barely studied. Tough things that, I presume, noone really wants to look at. Their results depict the reality of the disease, and it's a bleak...

@Sly Saint In this thread: https://www.s4me.info/threads/me-action-the-eu-committee-on-petition-is-preparing-a-resolution-on-me.13569/ :)

Excellent points w.r.t. the discussion on subjective & objective outcomes in an unblinded trial (bolding mine). @strategist sums up things very well. Hope you can read those posts @Hilda Bastian

Today (10 June) at 2PM CET BMSystems are doing a live webinar. It's open to everyone but it will be in French. You can register at: https://event.webinarjam.com/register/14/3824ru4

If these serious issues can be so concisely summed up, one can only hope the new Cochrane review board will quickly reach the same conclusion. It's so desperately needed :emoji_confounded:

@Hilda Bastian Years of clinical trials on ME/CFS point to the above criteria as being the correct ones to look at in ME/CFS. If a clinical trial is truly meant to help patients -- that is, it tests whether a treatment is safe for these patients and has an objectively measurable positive effect...

I cannot thank enough everyone who has been commenting on this thread to describe the consequences of the twisted science behind GET and CBT, either on their lives as patients or carers or generally on the medical and scientific fields. And for calling on doing better, much better, than harming...

Mod note: The reply by Lubet and Tuller was in response to an article by Sharpe and Greco, discussed here: Michael Sharpe: Mind, Medicine and Morals: A Tale of Two Illnesses (2019) BMJ blog - and published responses By Steven Lubet & David Tuller. Abstract: Link...

:banghead::banghead::banghead: They say there will be a subset analysis based on different diagnostic criteria, but they could very well just lump IOM, CCC or ICC with other criteria that do not require PEM. Here is a nice one too: And yet: But it's not like there could be any rating...