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We don’t actually care about the deflection point in a lactate curve on its own True exponential curves don't have deflections. it's like finding the corner of a circle There are lots of corners depending on our operational definitions

I found this thread on X interesting We are probably familiar with the BLa curve during an incremental exercise test As intensity increases BLa accumulates at a faster rate, approximating an exponential increase We can estimate a 'threshold' in this curve, but what is this threshold telling us?

That link is a good explanation from what I've read from pwME who don't have a known or obvious baseline. They can monitor their symptoms and pace to avoid worsening. I don't experience many symptoms, but during allergy season and immune/viral or whatever is going on can bring on immediate...

Editor’s summary Intracellular lipids are an important energy source for skeletal muscle during exercise and must be replenished afterward. Chan et al. investigated the role of the myokine BDNF in post-exercise metabolic reprogramming and recovery in skeletal muscle. Mice with a muscle-specific...

@Trish I've read about several similar experiences over the years. I also didn't experience PEM or delayed PEM until several years after onset and this was during the time period when I didn't have cognitive issues or OI either. This is why I feel most of my immediate "fatiguability"...

Some of us don't experience symptoms at all during the activities, in fact I sometimes get an adrenaline boost which is tricky in itself b/c it's pushing me to do more. I could go for a 45 min run and feel fine for the next 12-14 hours. I sleep well and feel ok the next morning and then the...

Same with my Mother.

This was in the news recently. Calgary judge rules woman with autism can seek MAiD Justice Colin Feasby said his decision will be stayed for 30 days so lawyers for the father of the woman can decide whether to file an appeal. “This is a terrible choice that should not be forced on MV, as...

Doctors need to get better at listening to our patients

Prodrome Glia is my #1 recommendation for anyone with #MECFS and #LongCovid with "neuro symptoms" (including brain fog, cognitive issues, migraine, headache, tinnitus etc). It comes in liquid form! If the capsules are sold out (as they often are) just buy the liquid. Its even easier to take for...

Which also includes cognitive impairment for pwME that worsens over time from PEM.

Merged thread Tam’s journey began with one of her family medicine patients in 2015. She couldn’t figure out what was causing their persistent fatigue, which was debilitating enough to keep them out of work. Tam said her patient ultimately had to seek that answer across the country...

Diagnosing dysautonomia is often partly a process of elimination. It also involves determining how and when symptoms occur and finding patterns that connect them. It could be caused by many other issues that haven't been diagnosed that brings on fatigability.

Being upright for too long brings on head pressure. It's related to OI in my experience. I also feel head pressure during delayed PEM but it feels more like a clamp wrapped around my forehead.

The team followed up on this finding with an exhaustive series of experiments encompassing protein-on-protein reactions, human and animal cell lines, lab models, and tissue and fluid samples from COVID-19 patients. This is the picture that emerged: When the coronavirus enters a cell of the...

The researchers began with two related core questions: Why is so little inflammation seen with SARS-CoV-2 in lung cells? And, for the people who don't recover in the first seven to 10 days, why do the symptoms get so much worse They started by screening all SARS-CoV-2 proteins to see which ones...

In lab experiments, the researchers identified a drug that quelled inflammation in human immune cells infected with SARS-CoV-2 and reduced symptoms in mice, suggesting that it may be possible to prevent deadly cytokine storms.

There are two stages that work through different signaling pathways. With the normal pathway, everything goes normally, and the virus replicates. When the immune cells pick up the virus, replication is defective, but it produces a lot of cytokines.

A 2nd pathway the virus sometimes takes to enter immune cells. This alternative pathway both stunts virus's ability to reproduce & prevents production of the 2nd immune signal-braking protein. The 1st protein is then able to spur rampant inflammation linked to severe symptom

The team found that when SARS-2 infects its first-phase targets, cells in the lining of lung, two viral proteins circulate within those cells—one that works to activate the immune system & a 2nd that, paradoxically, blocks that signal, resulting in little or no inflammation