Search results

:emoji_coffee:Stay well hydrated! ;) Coffee as a dietary strategy to prevent SARS-CoV-2 infection https://cellandbioscience.biomedcentral.com/articles/10.1186/s13578-023-01154-9

Wasn't sure if I should post this on the tea thread.

Abstract SARS-CoV-2 infects the oral mucosa and is shed in salivary fluids. Traditionally, tea has been used by various cultures to treat respiratory ailments. The objective of this study was to identify commercially available teas that can rapidly inactivate infectious SARS-CoV-2 in saliva...

“This is the first and largest systematic study evaluating brain pH and lactate levels across a range of animal models for neuropsychiatric and neurodegenerative disorders. Our findings may lay the groundwork for new approaches to develop the transdiagnostic characterization of different...

Full Title: Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment Abstract Increased levels of lactate, an end-product of glycolysis, have been proposed as a potential surrogate...

Introduction: Acupuncture analgesia (AA) is widely used in clinical practice. The autonomic nervous system (ANS) may be an important pathway for acupuncture signal transduction. However, real-time changes in autonomic function during AA and the effect of “needle sensation” remain unclear...

I am also interested in learning about lactate levels in the brain and how they negatively interplay with cognitive and physical activities.

Abstract Microneedle lactate sensors may be used to continuously measure lactate concentration in the interstitial fluid in a minimally invasive and pain-free manner. First- and second-generation enzymatic sensors produce a redox-active product that is electrochemically sensed at the electrode...

Earbud biosensors provide continuous monitoring of brain activity and lactate levels “Being able to measure the dynamics of both brain cognitive activity and body metabolic state in one in-ear integrated device that doesn’t intrude on the comfort and mobility of the user opens up tremendous...

Abstract Owing to the proximity of the ear canal to the central nervous system, in-ear electrophysiological systems can be used to unobtrusively monitor brain states. Here, by taking advantage of the ear’s exocrine sweat glands, we describe an in-ear integrated array of electrochemical and...

My M.E doctor told me back in 1992 that 2 of his pts developed acute M.E onset from a sting.

Neurological manifestations with basal ganglia involvement following Hymenoptera stings are rare and clinically ill-defined conditions. We present a patient with acute parkinsonism non-responsive to levodopa, who developed striatal lesions after a hornet sting. We report his response to...

Turns out hearing that "BLa increases exponentially at high intensity" is a bit of a pet peeve of mine :) Hopefully this thread can help how we think about this If you chose 'exponential' were you thinking about a lactate test? Or were you thinking about it some other way?

We need to keep in mind what information the test is trying to give us Try to picture *logarithmic* BLa responses during your exercise sessions, instead of exponential This might improve how we apply information from our tests to our training!

to predict real world performance LTs can be useful to extrapolate / predict transitions between intensity domains, or race performances This 2018 study found that differences in LTs could explain 30-60% of the variance in TT performance

So why do we care about lactate testing? Two reasons: to monitor change over time The major thing that matters for monitoring is consistency of the test LTs are reliable within around 5-10% (10-15 W) 12/

BLa⁻ production & release is greatest at the start of exercise V̇O₂ (OXPHOS) is still ramping up, and substrate (“anaerobic”) glycolysis must buffer the immediate energetic demand

BLa observed during a lactate test is the product of whole-body balance of: La⁻ production & release from working muscles into blood La⁻ oxidation/disposal by other tissues: muscle, heart, etc

If we continued our incremental lactate test and clamped workload above the lactate threshold, would it continue to increase exponentially? Nope! BLa accumulation *decelerates* over time, even at high intensity Because

We care about what our lactate curve predicts about our *constant workload* performance at every intensity What happens to BLa if we clamped workload during a lactate test and continued exercising at that constant workload? At lower intensities, something like this