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    Autoantibodies against muscarinic cholinergic receptor in chronic fatigue syndrome, 2003, Tanaka et al

    googling (as couldn't open full text) found the following which I don't know whether is of interest or too much of a sidebar. https://www.meresearch.org.uk/research/ach-review/ full paper about a page scroll down. it is from not long after this paper and is pulling together this with other 'of...
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    Autoantibodies against muscarinic cholinergic receptor in chronic fatigue syndrome, 2003, Tanaka et al

    I'm no expert in this area so would only be a second pair of eyes trying to use common sense and maths, but the link to the full text doesn't open for me so I don't know whether that is the same for others who might have more answers. I don't know whether there are more clues re: the y-axis that...
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    Trial Report Mixed methods system for the assessment of post-exertional malaise in myalgic encephalomyelitis/CFS: an exploratory study, 2024, Stussman +

    I hope that didn't come across as a 'you should have' , but it is useful to contextualise any methods or results whatever the subject area in the spirit of wanting to one day put the big picture together of these things. That's why I said it is a difficult job: PEM's going to be a tricky one...
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    Trial Report Mixed methods system for the assessment of post-exertional malaise in myalgic encephalomyelitis/CFS: an exploratory study, 2024, Stussman +

    I agree that studying PEM properly needs to be one of the priority areas. And definitely that it needs to be for more than 3 days (particularly as I can't imagine a set-up where all paricipants might be guaranteed to not have PEM re-triggered at some point e.g. from noisy or uncomfortable...
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    UK NICE 2021 ME/CFS Guideline, published 29th October - post-publication discussion

    Indeed, I am imagine as usual for these things from this area it will all be very back-to-front where the misinformation is information and what they call facts is misinformation. When people note these groups and individuals are closer to populist politicians I do have to agree. I suspect...
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    The Netherlands - €28.5 million ME/CFS research program - ZonMW funding awards announced April 2023

    yep it’s a weird delusional claim that has been pushed by the psychosomatic school to persuade bystanders they aren’t the ones who have self-interest but it’s those who might disagree with them who are biased. god knows how bad a bystander you have to be to try and pretend you are persuaded of...
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    No moderating impact of a medically unexplained etiology on the relationship between psychological profile and chronic pain, 2018, McNaughton et al

    and is sold as a first point of call diagnosis by certain individuals for whatever % they get away with quota-ing to the gatekeepers as 'you should be seeing and diagnosing'
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    COFFI - The international collaborative on fatigue following infection

    The CAC committee - catchy and coming from a background of marketing I find their choice of the term 'consumer' and 'advisory' insightful. Demonstrates they see a third party relationship (marketing to others who might persuade the 'consumer' they have to do x based on 'apparently Paul said it...
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    Framework for systematic reviews on psychological risk factors for persistent somatic symptoms & related syndromes & disorders (PSY-PSS) 2023 Hüsing

    Nope sadly as someone with an actual psychology degree I've watched as people from any other background than scientific psychology has decided to wonder themselves into coaching or 'brainwashing techniques' (CBT is just a delivery mechanism and someone with a qual in that isn't qualified to know...
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    Framework for systematic reviews on psychological risk factors for persistent somatic symptoms & related syndromes & disorders (PSY-PSS) 2023 Hüsing

    Precisely it. And only gets worse because you'd have to be self-flagellating given the requirement for literature reviews etc to, even if you could produce research that required 10x the time given (because timescales have been tallied to doing not-proper designs), you'd have few other papers to...
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    Framework for systematic reviews on psychological risk factors for persistent somatic symptoms & related syndromes & disorders (PSY-PSS) 2023 Hüsing

    Yes, psychosomatic was only 'under' the field of scientific psychology on the basis of it being one area that needed to be 'audited' and kept to standards, not because it is actually psychology. It, in a way is like if Criminology as a field was instead written by those who were criminals...
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    Framework for systematic reviews on psychological risk factors for persistent somatic symptoms & related syndromes & disorders (PSY-PSS) 2023 Hüsing

    Yes interesting to have the full list. Or alternatively we can take one from the psychiatry list and define the 'they think this exists, rather than admit it is their own bigotry' syndrome suffered by all those who believe this: and just call this billions and billions of pounds/dollars etc...
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    The effect of melatonin on irritable bowel syndrome patients with and without sleep disorders: a randomized double-blinded..trial, 2023,Dinevari et al

    I'm so used to reading dodgy methods I was cynical when reading their description of placebo-controlled etc so had a look. But it does seem they divided each group equally etc. And that when looking at the figures for the IBS stuff it did seem to have an effect just as much on those without...
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    No moderating impact of a medically unexplained etiology on the relationship between psychological profile and chronic pain, 2018, McNaughton et al

    Yes, the result without their wording says exactly that: more pain = more likelihood of psychological distress, whether the doctor was out that day/refused to look at someone based on their hair colour or not But their wording has tried to invert the causal logic. Which is very obvious when you...
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    No moderating impact of a medically unexplained etiology on the relationship between psychological profile and chronic pain, 2018, McNaughton et al

    Yep. They've inverted the wording/cause and effect for their own sly purposes. None of this is science or medicine or psychology in the science sense it is linguistics and usage of intellectual dishonesty/sophism to 'reframe' reality/lead the witness. If you think: those with greatest pain =...
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    No moderating impact of a medically unexplained etiology on the relationship between psychological profile and chronic pain, 2018, McNaughton et al

    Yep it is basically just spelling out the logic of the words then really isn't it - if you actually ascribed to those basic things of reality: like logic, reality, meaning. Someone with a lot of pain is someone with a lot of pain. Medically Unexplained actually means 'medicine available to...
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    Research news from Bhupesh Prusty

    and society prevents it - I've had individuals direcly ensuring I could neither get peace nor rest, to an extreme level, for most of my being ill. In fact I find it hard to name a point in decades where I didn't have at least one individual nearby who ensured I never had the rest 'normals' did...
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    Research news from Bhupesh Prusty

    Agreed on the sheer size of disability that needs to be attributed to actions of others. As if the disability size wasn't already huge enough with ME to begin with. You can neither easily hide it longish-term without taking people criticising you for things caused by the illness as personal...
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    Low dose Naltrexone - How might it work biologically in ME/CFS?

    It is interesting isn't it. My note re: the antidepressants analogy was really to note that the 'spiel' tends to always infer specific, where there are a lot of antidepressants these days that are used off-label or for other purposes. So I'm intrigued to be open-minded to the potential that...
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    Independent advisory group for the full update of the Cochrane review on exercise therapy and ME/CFS (2020), led by Hilda Bastian

    A carefully-chosen word there isn't it 'revisiting' vs any other possible alternatives that might have certain meaning/outcomes attached to them. And yes intriguing to track back the timing of decision to hire a head of governance (a year start-to-'in post' seems reasonable estimate) with...
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